Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Physiology Cell And Cell Components > Physiology Cell Junction > Flashcards

Physiology Cell Junction Flashcards

1
Q

What is cell junction

A

T is the connection between neighbouring cells and extracellular matrix

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Cell Junction is also called

A

Membrane junction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

There are 3 types of cell junctions

A

Occluding junction
Communicating junction
Anchoring junction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What is occluding junction

A

It is a junction that prevents intercellular exchange of materials, I.e, it prevents the movement of ion and molecules from one cell to another

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Tight junction is under occluding junction, what is tight junction?

A

Tight junction is an intercellular occluding junction that prevents movement of large molecules

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Tight junction is also called________ and it is the region where cell membrane of adjacent cells tightly fuse together

A

Zonal occludens

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Tight junction is present in the _________ of epithelial and endothelial cells of _____________, _____________, ______________

A

Apical margin, intestinal mucosa, wall of renal tubule, capillary wall

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Tight junction is made of a _______ which has ________ valves

A

Ridge, two

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Each half of the ridge consists of_________

A

Tight junction strands

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Proteins of tight junction are divided into two

A

-Tight junction membrane protein or integral membrane protein
-Scaffold or peripheral membrane protein

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Examples of tight junction membrane proteins are

A

Occludins, Claudia’s and JAMs- Junctional adhesion molecules

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Examples of Scaffold proteins are

A

Cingulin, symplekin and ZO 123

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Where are tight membrane proteins anchored

A

In the strands of the ridge and attach with their counterpart of neighbouring cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Scaffold proteins attach

A

With tight junction proteins and strengthen the anchoring in the rudges

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Function of tight junction

A

-Strength and stability
-Selective permeability- forms Selective barrier in small molecules and total barrier in large molecules
-Fencing function- prevents lateral movements of proteins and lipids in cell membrane
-Maintenance of cell polarity- fencing function maintains cell polarity by keeping proteins in tha apical region of cell membrane
-blood Brain barrier- tight junction of brain capillaries form the brain blood barrier w prevents entry of many substances from capillary blood to Brian tissue

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Barrier function of tight junction regulates what

A

Regulates the interchange of ions, water and variety of macromolecules between the cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Fencing function maintains the different composition of proteins and lipids in the _________and _________l plasma membrane T or F

A

Apical and basolateral

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Because of fencing function, tight junction js referred to as

A

Impermeable junction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

What are the exceptions of materials that can pass through blood Brain barrier

A

Lipid soluble substances like drugs, steroid hormones

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Diseases caused by mutation of genes encoding proteins of tight junction

A

-Hereditary deafness
-Ichthyosis
-Sclerosing cholangitis- inflammation of bile duct causing obstruction
- hereditary hypomagnesemia- low level of mag in the blood
- synovial sarcoma- soft tissue cancer

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Inflammation of bile duct is called

A

Sclerosing cholangitis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

What are communicating junctions

A

They are cell junctions that permit intercellular exchange of substances, I.e, they permit movement of ions and molecules from one cell to another

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Types of communicating junction

A

-gap junction
- chemical synapse

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

What is a gap junction

A

It is an intercellular communicating junction that allows passage of ions and small molecules between cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

Gap junction is also called

A

Nexus

26
Q

Gap junction is present in the heart and basal part of epithelial cells

A

True

27
Q

Go to your jotter to read structure of gap junctions

A
28
Q

Each half of channel in gap junction is surrounded by 6 subunits of proteins called

A

Connexins or connexons

29
Q

Function of gap junction

A

• diameter of gap junction is between 1.5nm to 3nm so it allows ions, amino acids and other substances with molecular weight less than 1000 in
- it activates rapid propagation of action potential from one cell to another
• helps in exchange of chemical messengers between cell

30
Q

In gap junction, diameter of channel is regulated by

A

Intracellular calcium ions

31
Q

What.happens when the concentration of intracellular calcium ion increases

A

The protein subunits of connexin cone together by sliding, this decreasing diameter of channel

32
Q

Diameter of channel is regulated by

A

PH, neurotransmitters, electric potential, hormones

33
Q

What is chemical synapse

A

It is the junction between a nerve fiber and a muscle fiber or between two nerve fibers, in which signals are transmitted by release of chemical transmitters

34
Q

Disease caused by mutation of genes of connexins

A

Deafness
Keratoderma
Cataract
Peripheral neuropathy
Heterotaxia

35
Q

What us peripheral neuropathy

A

Damage of nerves of peripheral nervous system

36
Q

Abnormal arrangement of organs or parts of the body in relation t9 left right symmetry is

A

Heterotaxia

37
Q

What are anchoring junctions

A

Junctions that provide strength to cells by acting as mechanical attachment

38
Q

Junctions that provide strong mechanical attachments between two cells or cells and its extracellular matrix is called

A

Anchoring cells

39
Q

Which junction is responsible for the structural integrity of tissues

A

Anchoring junction

40
Q

Anchoring junctions are present in tissues like

A

Heart and epidermis of skin

41
Q

Firm attachment between 2 Cells or a cell ad extracellular matrix is provided by

A

Actin filament or intermediate filaments

42
Q

Anchoring junctions can be divided into four based on actin filaments attachment and intermediate filament attachment

A

Actin - adherens junction(cell to cell)
Focal ashesion( cell to matrix)
Intermediate- desmosome(cell to cell)
Hemidesmosome(cell to matrix)

43
Q

What are adherens junction

A

Cell to cell junction that connects actin filament of one cell to another cell

44
Q

In places like epithelial lining, the cell forms a continous adhesion called

A

Zonula adherens

45
Q

Adherens junctions are present in the _________ between branches of cardiac muscles

A

Intercalated discs

46
Q

During the contraction and relaxation of the heart the cardiac muscles fibers are held together by which junction

A

Adherens junction

47
Q

In adhesion junction, Membrane of adjacent cells are held together by transmembrane proteins called

A

Cadherins

48
Q

What is focal adhesion

A

Cell to matrix junction that connects actin filaments of a cell to extracellular matrix

49
Q

In epithelial of various organs, which junction connects cells to their basal lamina

A

Focal adhesion

50
Q

Transmembrane proteins in focal adhesion which holds cell membrane and matrix together is called

A

Integrins

51
Q

What is desmosome

A

It is a cell to cell junction that connects intermediate filaments to 2 adjacent cells

52
Q

Desmosome is also called

A

Macula adherens

53
Q

Intermediate filaments are attached with thickened patches T or F

A

True

54
Q

Transmembrane proteins involved in desmosomes are mainly

A

Cadherins

55
Q

What is hemidesmosome

A

It is a cell to matrix junction, which connects intermediate filaments of the cell to extracellular matrix

56
Q

Hemidesmosome us like half of desmosome and thickening of membrane of only one cell occurs T or F

A

True

57
Q

Hemidesmosome is known as hemidesmosome or

A

Half desmosome

58
Q

Mostly hemidesmosomes connect cells with their _________

A

Basal lamina

59
Q

Proteins involved in hemidesmosomes are

A

Integrins

60
Q

List the 3 applied physiology in cell junction

A

Dysfunction of adherens and focal junction leads to…..
Dysfunction of desmosome causes
Dysfunction of hemidesmosome causes…..

61
Q

What are cell adhesion molecules

A

Physiology Cell And Cell Components (5 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions