Physiology Cell Death Flashcards
Cell death occurs in 3 ways
Autophagy
Apoptosis
Necrosis
Autophagy is also called
Autophagocytosis
Explain the process of autophagy
Involves formation of autophagosome which fuses with lysosomes, lysosomal enzymes causes destruction of organelles by protein degradation
Autophagy is a non apoptotic cell death T OR F
True
What is apoptosis
Natural or programmed death of cells under genetic control
Function of apoptosis
- plays vital role in cellular homeostasis
- used fir removal of cell damaged beyond repair
Go back to your jotter and read examples of apoptosis
Yes ma
Apoptosis removes autoregressive T cells and prevenst autoimmune disorder T or F
True
Activation of apoptosis is by
Removal of positive signals
Arrival of negative signals
What are positive signals and examples
Signals responsible for the long time survival of the cell stimulated by other cells or chemical kini like nerve growth factor (neurons)
Interleukin 2
What are negative signals
They are external or internal stimuli that activate apoptosis
External stimuli of negative signals are applied by
Death receptor gland and stimulus molecule
What are death receptor glands
Substances that bind specific cell membrane receptors together and initiate apoptosis
Types of death receptor glands
Tumor necrosis factor alpha
Fas ligand
TRIAL ligand
TNF alpha is a cytokine secreted by many cells and activated by ___________ and ___________
T lymphocytes and natural killer cells
