Physiology Flashcards
Most common reason for failed blood transfusions
Clerical Error
Deficiency of factor VIII
Hemophilia A, X-linked recessive
Deep tissue, joint and post-Sx bleeding
Hemophilia A, X-linked
Deficiency of Factor IX
Hemophilia B, Christmas Disease
Inhibits enzyme vitamin K epoxide reductase
Warfarin
Vitamin K deficiency
decreased synthesis of factors II, VII, IX, X, protein C and S
Antithrombin inhibits activated forms of
factors II, VII, IX, X, XI, and XII
enhances the activity of antithrombin
Heparin
Changes Plasminogen into Plasmin
tPA
Factor V Leiden mutation
factor V resistant to inhibition by activated protein C
4 steps of Primary Hemostasis
- Transient constriction of BVs
- Plt adhesion to disrupted vessel
- Plt Degranulation
- Plt Aggregation
vWF
binds to exposed collagen upon endothelial damage
How to link Platelets
Fibrinogen binds GpIIb/IIIa receptors
Deficiency of GpIb
Bernard-Soulier Syndrome
Deficiency of vWF
von Willebrand disease
Abciximab
blocks GpIIb/IIIa
Deficiency of GpIIb/IIIa
Glanzmann Thrombasthenia
Irreversibly blocked by Clopidogrel and Ticlopidine
ADP receptor
Inhibits cyclooxygenase (TXA2 synthesis)
Aspirin
activates vWF to bind GpIb
Ristocetin, useful to diagnose vonWillebrand disease
Inhibit ADP-induced expression of GpIIb/IIIa
Clopidogrel and Ticlopidine
Increased ESR
infections, autoimmune diseases, malignant neoplasms, GI disease (UC), pregnancy
Decreased ESR
polycythemia, sickle cell anemia, CHF, microcytosis, hyperfibrinogenemia
Who you gunna call?
Ghostbusters!
