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First Aid Hem/Onc > Physiology > Flashcards

Physiology Flashcards

1
Q

Most common reason for failed blood transfusions

A

Clerical Error

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2
Q

Deficiency of factor VIII

A

Hemophilia A, X-linked recessive

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3
Q

Deep tissue, joint and post-Sx bleeding

A

Hemophilia A, X-linked

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4
Q

Deficiency of Factor IX

A

Hemophilia B, Christmas Disease

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5
Q

Inhibits enzyme vitamin K epoxide reductase

A

Warfarin

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6
Q

Vitamin K deficiency

A

decreased synthesis of factors II, VII, IX, X, protein C and S

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7
Q

Antithrombin inhibits activated forms of

A

factors II, VII, IX, X, XI, and XII

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8
Q

enhances the activity of antithrombin

A

Heparin

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9
Q

Changes Plasminogen into Plasmin

A

tPA

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10
Q

Factor V Leiden mutation

A

factor V resistant to inhibition by activated protein C

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11
Q

4 steps of Primary Hemostasis

A
  1. Transient constriction of BVs
  2. Plt adhesion to disrupted vessel
  3. Plt Degranulation
  4. Plt Aggregation
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12
Q

vWF

A

binds to exposed collagen upon endothelial damage

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13
Q

How to link Platelets

A

Fibrinogen binds GpIIb/IIIa receptors

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14
Q

Deficiency of GpIb

A

Bernard-Soulier Syndrome

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15
Q

Deficiency of vWF

A

von Willebrand disease

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16
Q

Abciximab

A

blocks GpIIb/IIIa

17
Q

Deficiency of GpIIb/IIIa

A

Glanzmann Thrombasthenia

18
Q

Irreversibly blocked by Clopidogrel and Ticlopidine

A

ADP receptor

19
Q

Inhibits cyclooxygenase (TXA2 synthesis)

A

Aspirin

20
Q

activates vWF to bind GpIb

A

Ristocetin, useful to diagnose vonWillebrand disease

21
Q

Inhibit ADP-induced expression of GpIIb/IIIa

A

Clopidogrel and Ticlopidine

22
Q

Increased ESR

A

infections, autoimmune diseases, malignant neoplasms, GI disease (UC), pregnancy

23
Q

Decreased ESR

A

polycythemia, sickle cell anemia, CHF, microcytosis, hyperfibrinogenemia

24
Q

Who you gunna call?

A

Ghostbusters!

First Aid Hem/Onc (8 decks)

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