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First Aid Hem/Onc > Pathology 3 > Flashcards

Pathology 3 Flashcards

1
Q

Lymphoid or myeloid neoplasms with widespread involvement of BM. Tumor cells in peripheral blood.

A

Leukemia

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2
Q

Discrete tumor masses arising from LN.

A

Lymphoma

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3
Q

Acute inflammatory response to infection.

A

Leukemoid reaction, increased WBC count with left shunt and increase leukocyte ALP

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4
Q

Reed-Sternberg Cells

A

Hodgkin Lymphoma

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5
Q

Localized, single group of nodes; contiguous spread

A

Hodgkin Lymphoma

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6
Q

Bimodal Distribution

A

young adulthood and >55y/o

Hodgkin Lymphoma

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7
Q

Associated with EBV

A

Hodgkin Lymphoma

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8
Q

Most common subtype of Hodgkin Lymphoma

A

Nodular Sclerosis

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9
Q

Peak age for NHL

A

20-40

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10
Q

IgM heterophile Antibody (+)

A

Infectious Mononucleosis

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11
Q

Confirmatory test for Infectious mononucleosis

A

EBV viral Capsid Antigen

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12
Q

CD15+ and CD30+

A

Reed-Sternberg in HL

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13
Q

t(8;14)

A

translocation of c-myc and heavy-chain Ig

Burkitt Lymphoma

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14
Q

Starry Sky

A 
sheets of lymphocytes with interspersed macrophages
Burkitt Lymphoma (NHL)
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15
Q

Endemic Burkitt Lymphoma

A

Jaw Lesion

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16
Q

Sporadic Burkitt Lymphoma

A

Pelvis or Abdomen

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17
Q

t(14; 18)

A 
Follicular Lymphoma (bcl-2 activation)
Diffuse large B cell Lymphoma - most common NHL
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18
Q

t(11; 14)

A

Translocation of cyclin D1 and heavy chain Ig
Mantle cell lymphoma
CD5+

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19
Q

Lytic bone lesions, hypercalcemia, caused by HTLV-1

A

Adult T-cell Lymphoma

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20
Q

Lymphocytes with cerebriform nuclei

A

Mycosis fungiodes/ Sezary Syndrome

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21
Q

Pautrier microabscesses

A

Aggregates of neoplastic T cells in epidermis

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22
Q

Monoclonal Plasma Cell “fried egg appearance”

A

Mulitple Myeloma

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23
Q

Hypercalcemia, renal insufficiency, anemia, bone lytic lesions

A

Multiple Myeloma

24
Q

Large amounts of IgG and IgA, most common primary tumor arising within bone in the elderly

A

Mutliple Myeloma

25
Q

Bence Jones protein

A

Multiple Myeloma

26
Q

Rouleaux Formation

A

RBCs stacked like poker chips, Multiple Myeloma

27
Q

IgM spike with no lytic bone lesions

A

Waldenstrom macroglobulinemia

28
Q

M-spike with no features of multiple myeloma, no lytic lesions, no hyper[Ca2+], no AL amyloid, no Bence-Jones Proteinuria

A

MGUS - monoclonal gammopathy of undetermined significance

29
Q

High Serum IL-6

A

Multiple Myeloma because of increased plasma cells

30
Q

neutrophils with bilobed nuclei typically seen after chemo

A

Pseudo-Pelger-Huet Anomaly

31
Q

Cancer Associated with Down’s

A

Acute Lymphoblastic Leukemia/Lymphoma and AML

32
Q

TdT+, CD10+, In children <15y/o

A

ALL (B-cell type)

33
Q

Where ALL can spread to

A

CNS and testes

34
Q

Cancer with mediastinal Thymic Mass

A

T-cell ALL

35
Q

Smudge Cells

A

Chronic Lymphocytic Leukemia (CLL)

36
Q

Neoplastic Proliferative of Naive B cells

Co-express CD5 and CD20

37
Q

Mature B-cell tumor in elderly

A

Hairy Cell Leukemia

38
Q

Stains TRAP (tartrate-resistant acid phosphatase)

A

Hairy Cell Leukemia

39
Q

Dry Tap on aspiration

A

Hairy Cell Leukemia

40
Q

Tx of Hairy Cell Leukemia

A

2-CDA, cladribine which is an adenosine analog inhibiting adenosine deaminase

41
Q

Cells have filamentous hair-like projections

A

Hairy Cell Leukemia

42
Q

Auer Rods

A

Acute Myelogenous Leukemia

43
Q

Increased circulating myeloblasts on peripheral smear in adults

44
Q

Responds to all-trans retinoic acid (ATRA)

A

Induces differentiation of myeloblasts, txs AML-M3

45
Q

Common presentation of AML

46
Q

Philadelphia Chromosome

A

t(9; 22) CML bcr-abl hybrid

47
Q

Tx for CML

A

Imatinib, inhibits bcr-abl TK

48
Q

t(15; 17)

A

M3 type of AML (responsive to ATRA)

49
Q

Alpha-fetoprotein

A

heptoma, germ cell neoplasms

50
Q

CEA

A

breast and colon Cancer

51
Q

CA125

A

Ovarian Cancer

52
Q

PSA

A

Prostate Cancer, more for follow-up than diagnosis

53
Q

Proliferation of monoblasts, lack MPO, blasts infiltrate gums

A

Acute Monocytic Leukemia

54
Q

Proliferation of megakaryoblasts, lack MPO, associated with Downs before 5y/o

A

Acute Megakayoblastic Leukemia

55
Q

Jenny I got your number

First Aid Hem/Onc (8 decks)

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