Physio Flashcards
Insulin and Glucagon Are Synthesized in
Islets of Langerhans
Insulin and Glucagon Are Synthesized and Metabolized Like
Most Peptide Hormones.
as large preprohormone
connecting (C) peptide (which connects the
two peptide chains of insulin)
In the case of the beta cells, insulin and connecting (C) peptide are released into
circulating blood in equimolar amounts.
C peptide levels can be measured with
radioimmunoassay
C peptide levels is a measure of
beta cell function in diabetic patients treated with insulin
Insulin Is a Hormone Associated With
Energy Abundance.
insulin is secreted and permits these nutrients to be used by tissues for
energy and anabolic processes;
Most of the Actions of Insulin Are Achieved Through
Autophosphorylation of Receptors.
autophosphorylation of the β subunits on tyrosine residues results in
phosphorylation of other intracellular proteins and enzymes, which mediates a multitude of responses.
Muscle, Insulin Promotes
Uptake and Metabolism of Glucose
In the Liver, Insulin Promotes .. and inhibits..
Glucose Uptake and Storage and Inhibits Glucose Production.
In Adipose Tissue, Insulin Facilitates
Glucose Entry Into Cells.
Insulin Has Little Effect on
Glucose Uptake and Use by the Brain.
Effects of Insulin on Fat Metabolism
Insulin Enhances Storage and Inhibits Mobilization of Fatty Acids.
In Adipose Tissue,
