Phys: Reg Of Blood Pessure Flashcards
Normal blood pressure range for systolic and diastolic:
S: less than 120
D: less than 80
Elevated blood pressure numbers:
S: 120-129
D: less than 80
HTN stage 1 blood pressure numbers:
S: 130-139
D:80-89
HTN stage 2 blood pressure numbers:
S: 140 or higher
D: 90 or higher
Hypertensive crisis numbers:
S: higher than 180
D: higher than 120
Risk factors for HTN:
-age
-obesity
Physical inactivity
-high sodium diet
-excess alcohol
-family history
-black>white>asian
Complications of elevated blood pressure (non-ocular):
-coronary artery disease (CAD)
-left ventricular hypertrophy (LVH)
-heart failure (HF)
-atrial fibrillation
Complications of high blood pressure (ocular):
-Retinopathy
-papilledema
Papilledema:
Swelling around optic disk secondary to increased ICP
Blood pressure = ____ X _____
CO X TPR
How can atrial pressure be increasesd? :
-constricting arterioles which increase TPR
-constricting large vessels which increase VR and CO
-increasing CO, heart rate, and contractility
Short term regulators of blood pressure:
-baroreceptors
-chemoreceptors
-CNS ischemic response
Intermediate regulators of blood pressure:
-renin angiotensin aldosterone system
Long term blood pressure regulators:
-kidney regulation of sodium and water
What are the two mechanisms for regulating blood pressure?
baroreceptor reflex and renin angiotensin system
The baroreceptor reflex:
-baroreceprors detect changes in arterial pressure
-signals sent to medulla of the brainstem
-heart rate adjusted
What carries the afferent fibers of the baroreceptors in the carotid sinus?
Glossopharyngeal nerve
What nerve carries parasympathetic impulses of the carotid sinus?
Vagus nerve
What causes renin to released?
Low blood volume
Where is renin synthesized and stored?
In the modified smooth muscle cells in afferent arterioles of the kidney
When is renin released?
In response to a fall in pressure
What does renin act on?
Angiotensinogen to form angiotensin I peptide
What two things is angiotensin II involved in?
-vessel constriction to increase TPR and BP
-release the aldosterone from adrenal cortex for Na+ and H2O absorption to increase SV and BP
As Na+ intake is decreased, ________ levels increase significantly
Renin
Exercising muscles receive up to ___% of the total cardiac output during periods of activity
85%
What happens to mean blood pressure during exercise and why?
There is a modest increase in mean blood pressure as vasodilation within the skeletal muscles significantly decreases the total vascular resistance
Sympathetic nerve fibers innervate all vessels EXCEPT:
Capillaries and precapillary sphincters and some metarterioles
What does the innervation of small arteries and arterioles allow for?
Sympathetic nerves to increase vascular resistance
How are large veins to the heart innervated?
Sympathetically
What is the parasympathetic nervous system important for?
Control of heart rate via the vagus nerve
Where are teh vasoconstrictor fibers distributed?
All throughout the segments of circulation
Where are there more vasoconstrictor fibers?
Kidneys, gut, spleen, skin
Blood vessels are only innervated by ____ fibers via ____
SNS, alpha 1
What does the Vasomotor center do?
Transmit impulses downward through the cord to almost all blood vessels
Vasomotor center is located _____ in the medulla and the lower ____ of the pons
Bilaterally, 1/3rd
What is the Vasomotor center composed of?
Vasoconstrictor, vasodilator, and sensory area
The continuous signal s to sympathetic nerve fibers via vasoconstrictor area of VMC is called….
Sympathetic vasoconstrictor tone
What is the neurotransmitter for the vasoconstrictor nerves?
Norepinephrine
What can exert powerful excitatory or inhibitory effects on the VMC?
Higher centers of the brain (ie hypothalamus)
How can the VMC increase arterial pressure within seconds?
-constricting all arterioles -> Increase TPR
-constricting large vessels of circulation -> increase VR -> increase CO
-directly increase CO by increasing HR and contractility
Where are baroreceptors located?
-walls of the carotid bifurcation(carotid sinus)
-walls of aortic arch