Phospholipids Flashcards
Phosphatidylcholine
AKA
Lecithin
Phosphatidylcholine
Function
MC in Body
Concentrated in lung surfactant
Helps organize lipid bilayer
Phosphatidylserine
Highest concentration of n-3 and n-6 at sn-2
Marker for apoptosis
Clotting
Bone formation
Phosphatidylethanolamine
Highly concentrated in brain and liver
Phosphatidylglycerol
Precursor to cardiolipin
Cardiolipin
Found in inner mitochondrial membrane
Phosphatidylinositol
Membrane anchoring and cell signaling
Involved in phospholipase C pathway
Phosphatidylserine found normally
Inner leaflet of plasma membrane
When phosphatidylserine moves to outer leaflet, it signals
WBC for apoptosis
Ether phospholipids
Have ethers bond rather than ester bond
Main ether phospholipids in body
Plasmologen
Platelet activating factor
Plasmalogen
Polar head
Ethanolamine
Plasmalogen
Function
Concentrated in brain, heat, nerve, and muscle tissue
50% of phospholipids in brain
Platelet activating factor
Polar head
Choline
Platelet activating factor
Function
Stimulates clotting
Activates protein kinase C
Causes inflammation
Parent of all sphingolipids is
Ceramide
Ceramide made of
Sphingosine + FA
Ceramide important in
Cell signaling
Regulation of cell death
Water permeability of skin
Too much ceramide can cause
Inflammation
Cell death
Ceramide derivatives
Sphingomyelin
Ganglioside
Cerebroside
Globoside
Sphingomyelin made of
Sphingosine
FA
Phosphate
Cholin
Cerebrosides
+1 sugar
Usually glucose or galactose
Globoside
+2 sugars
Usually glucose, galactose, or N-acetylgalactosamine
Ganglioside
+3 or more
Sugars + N-acetylneuraminic Acid
