Phosphodisterase Type 5 (PDE5) Inhibitors Flashcards
1
Q
Give 3 PDE5 inhibitors
A
- Sildenafil
- Vardenafil
- Tadalafil
2
Q
What is the mechanism of action of PDE5 inhibitors?
A
Inhibit phosphodiesterase type 5
3
Q
What does PDE5 do?
A
Breaks down cGMP
4
Q
What does cGMP do?
A
Causes relaxation and vasodilatation of the peripheral arteries, and increased blood flow to the penis, resulting in penile engorgement
5
Q
Where is cGMP found?
A
Found naturally in the lungs, and is produced following sexual stimulation in the corpus cavernosum of the penis
6
Q
How does the inhibition of PDE5 lead to the effects of PDE5 inhibitors?
A
Inhibition of cGMP breakdown will increase cGMP levels, and this will relieve pulmonary hypertension and improve the ability of a male to have an erection
7
Q
What are the routes of delivery of PDE5 inhibitors?
A
- PO
- IV
