Adenosine Flashcards
What is the mechanism of action of adenosine?
Binds to G-protein coupled receptors, which slows heart rate
How is adenosine administered?
IV
What should be done if adenosine is to be administered via central line (compared to peripheral line)?
Lower doses should be used
Why might repeated doses of adenosine need to be given?
Due to half life of <10 seconds
What are the indications for adenosine?
Supraventricular tachycardia
What is the role of adenosine in supraventricular tachycardias?
First line for diagnosis and therapeutic relief
What effect does adenosine have on SVT?
If true SVT, adenosine should revert rhythm to sinus
When is adenosine contraindicated?
- Asthma
- COPD
- Decompensated heart failure
- Cardiac transplant patients
- 3rd degree AV block
- Sick sinus syndrome
- Severe hypotension
When should adenosine be used with caution?
- AF and atrial flutter with accessory pathways
- 1st degree AV block
- Bundle branch block
- Autonomic dysfunction
- Recent MI
- Severe heart failure
- Stenotic and valvular heart disease
- Pericarditis
- QT interval prolongation
What monitoring is required with adenosine?
Cardiac monitoring is essential during administration of adenosine
Why is cardiac monitoring required when administering adenosine?
To check for return of sinus rhythm
What might adenosine interact with?
- Theophylline
- Aminophylline
- Caffeine
What might happen if adenosine is given with theophylline, aminophylline, or caffeine?
May interact with adenosine for binding to G-protein coupled receptors
What are the common side effects of adenosine?
Abdominal discomfort; Arrhythmias Chest pain (discontinue) Dizziness Dry mouth Dyspnoea Flushing Headache Hypotension (discontinue if severe)
What are the uncommon side effects of adenosine?
Bradycardia (discontinue if asystole or severe bradycardia occur)
Hyperhidrosis
Nervousness
