Phosphate Metabolism

Question 1

What is the role of phosphate in physiology

Answer 1

Unit of energy currency - ATP
Phospholipid bilayers
Nucleotides
Switching proteins on and off
Bone mineral

Question 2

What is the normal body phosphate

Answer 2

500-800g
1% total body weight
90% bone mineral

Question 3

What can low phosphate cause

Answer 3

Poor bone mineralisation which can cause pain and fractures or rickets

Question 4

What can be caused if phosphate is too high

Answer 4

Excessive formation of hydroxyapatite
Deposition of hydroxyapatite in any tissues other than bones

Question 5

What are dietary sources of phosphate

Answer 5

Protein
Dairy
Soy
Seeds and nuts

Question 6

Where is phosphate reabsorbed

Answer 6

80% reabsorbed in the proximal convoluted tubule

Question 7

How is phosphate metabolism regulated

Answer 7

Parathyroid hormone
1,25 dihydroxyvitamin D
FGF-23

Question 8

How does parathyroid hormone regulate phosphate

Answer 8

High PTH = increases loss of phosphate