Collagen Basics

Question 1

What forms a collagen fibre

Answer 1

Amino acid chains join to form collagen molecules which are made up of a triple helices known as tropocollagen to form a fibril, many fibril forms a collagen fibre

Question 2

What does 3 collagen chains form

Answer 2

3 stranded tropocollagen molecule

Question 3

How are the tropocollagen molecules and fibrils held together

Answer 3

Covalent cross links

Question 4

When collagen is been formed what happens to the ends of the strands

Answer 4

They are cleaved off

Question 5

Within a between the triple helix and tropocollagen molecule there are cross links, what do they need

Answer 5

Copper

Question 6

What breaks down collagen

Answer 6

Proteinases such as collagenases and Cathepsin K in bone

Question 7

Where is type I collagen found

Answer 7

Bone, tendon, ligaments, skin

Question 8

Where is type II collagen found

Answer 8

Articular cartilage and vitreous

Question 9

Where is type III collage found

Answer 9

Wound healing

Question 10

Where is Type IV collagen found

Answer 10

Basal lamina

Question 11

Where is type V collagen found

Answer 11

Cell surfaces

Question 12

Where is type X collagen found

Answer 12

Growth plate