Normal Bone Function Flashcards

1
Q

What is the purpose of the skeleton

A

Raise us from the ground against gravity
Basic body shape
Transmits body weight
System for movement
Protects vital structures
Houses bone marrow
Mineral storage

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2
Q

How many bones does a adult have

A

206

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3
Q

What are the different classifications of bone

A

Long bones
Short bones
Flat bones
Irregular bones
Sesamoid bones

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4
Q

WhAt are long bones

A

Tubular shape with hollow shaft and ends expanded for articulation with other bones

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5
Q

What are short bones

A

Cuboidal in shape

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6
Q

What are flat bones

A

Plates of bone often curved protective function

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7
Q

What are irregular bones

A

Various shapes

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8
Q

What are seamoid bones

A

Round oval nodules in a tendon

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9
Q

What are the different structures of bone which are visible by eye

A

Cortical
Trabecular

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10
Q

What is a cortical structure of bone

A

Compact
Dense solid
Only space is for cells and blood vessels

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11
Q

What is trabecular bone

A

Cancellous
Spongy bone
Network of bony struts
Which look like sponge
Many holes
Filled with bone marrow

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12
Q

What are the type of bone structure which cannot be seen by the eye

A

Woven and lamellar

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13
Q

What is woven bone

A

Disorganised
No clear structure
Made quickly

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14
Q

What is lamelllar bone

A

Organised
Layered structure
Made slowly

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15
Q

What is and adult bone composed of

A

Mineral
Organic matrix = collagen and non-collagenous proteins
Water

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16
Q

What is bone

A

Bone is a composite

17
Q

What does mineral in the bone provide

A

Stiffness

18
Q

What does collagen in the bone provide

A

Elasticity

19
Q

What is bone modelling

A

Gross shape is altered so bone is added or taken away

20
Q

What is bone remodelling

A

All of the bone is altered so new bone replaces the old bone

21
Q

What are the cells of bone

A

Osteoclasts
Osteoblasts
Osteocytes
Bone lining cells

22
Q

What are characteristics of osteoclasts

A

Multi-nucleated

23
Q

What are characteristics of osteoblasts

A

Plump and cuboidal shape

24
Q

What are characteristics of osteocytes

A

Stellate
Entombed in bone

25
Q

What are characteristics of bone lining cells

A

Flattened
Lining the bone

26
Q

What is the origin of osteoblasts

A

Mesenchymal stem cells

27
Q

What do osteoblasts do

A

Form bone
Produce type I collagen
Deposit calcium
High alkaline phosphatase activity
Make non-collagenous proteins
Secrete factors that regulate osteoclasts eg RANKL

28
Q

What do osteoclasts do

A

Resorb bone
Dissolves the mineralised matrix
Breakdown the collagen in bone
High expression of TRAP and cathepsin K

29
Q

Reasons for bone remodelling

A

Form bone shape
Replace woven bone with lamellar bone
Reorientates fibrils and trabeculae in favourable direction for mechanical strength
Response to loading
Repair damage
Obtain calcium