Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Module 4 > Pharmokinetic > Flashcards

Pharmokinetic Flashcards

1
Q

What are key factors from previous lecture that affect distribution

A

Lipid soluble

Protein bound

Accumulation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What is Vd

A

Volume distribution

=fluid volume in which drug seems be be dissolved

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

If Vd is high what does that mean

A

Lipid soluble

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Give ranges according to drug position in body Vd

A
  1. 1-0.2 = plasma
  2. 4-0.7 = ECF

1> = total body

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What is Vd equation

A

Total volume of drug

Plasma concentration

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What is loading dose

A

Initial dose to reach desired plasma level

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What is loading dose equation

A

Vd x Ceff

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What is Ceff

A

Effective concentration

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What do you divide Vd by to get idea of where will go in blood?

A

Weight

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What are 4 factors that effect Vd

A

Ion trapping - ph of compartments different so attract different drugs

Irreversible receptor binding

Highly lipid soluble

Accumulated

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What factors of the animal may affect Vd

A 
Age 
Weight 
Disease 
Dehydration
Specie s
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Stages of metabolism of drug

A

Drug

Phase one
Derivative

Phase two
Conjugate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What is the point of metabolism

A

Make water soluble so can be excreted

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Phase one

A

Adding or joining chemical group to make more reactive

Oxidation
Reduction
Hydrolysis
Hydration

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Enzymes involved in metabolism

A

P450 cytochrome

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Phase 2

A

Joining or adding of molecule

17
Q

Common conjugated of phase 2

A

Acetyl (not dogs) - acetylation

Sulphate - sulphination
Methyl- methylation

Glucuronyl (not cats)

18
Q

What are 3 factors that affect metabolism

A

First pass metabolism

Microsomal enzymes

Others

19
Q

What is first pass metabolism

Problem

A

Drug is metabolised by git before reaches systemic

Poor bioavailability
Need large dose

20
Q

What are microsomes enzymes

A

Some drugs activate

Increase metabolism
Increase or decrease toxicity

21
Q

Other factors that affect metabolism

A

Species
Previous drug therapy (microsomal)
Disease
Age

22
Q

What is clearance

A

Rate that blood is cleared of drug

23
Q

What is the name of when drug is reabsorbed

A

Enterohepatic circulation

24
Q

What happens with enterihepatic circulation

A

Phase 2 molecule breaks off

25
Q

Zero order kinetic

A

Elimination is proportional to time

26
Q

First order kinetics

A

Concentration of drug decreases exponentially with time

27
Q

Pharmokinetics

A

What the body does to the drug

ADME

Module 4 (5 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions