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FCATDESA > Pharmakologie > Flashcards

Pharmakologie Flashcards

1
Q

Propofol Wirkung

A

Cl- Einstrom am GABAa Beta1 Rezeptor

NMDA Inhibitor

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2
Q

Propofol Verteilungsvolumen

A

228ml/kg initial bis zu 10l/kg steady state

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3
Q

Propofol kontextsensitive HWZ

A

2h 16min

8h 41min

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4
Q

Propofol Clearance

A

2800ml/min

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5
Q

Propofol Eiweissbindung

A

98%

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6
Q

Wie schaut Propfol aus

A
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7
Q

pKA Propofol

A

11

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8
Q

Ketanest - physikalische Eigenschaften

A
  • wasserlöslich
  • pH 3,5 - 5,5

pKA 7,5

  • fettlöslich
  • Proteinbindung 25%
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9
Q

Ketanest - Wirkmechanismus

A

NDMA - Rezeptorantagonist an der Ca2+ Pore

  • antagonist at serotoninergic, muscarinic, nicotinic and monoaminergic receptors
  • Partialagonist KOP/DOP
  • Partialantagonist MOP
  • inhibiert Natriumkanäle
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10
Q

Ketantest - Metabolisierung

A

hepatisch

  • Norketamin 1/3 aktiv
  • Dehydronorketamin kaum aktiv

renal ausgeschieden

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11
Q

Dosierung Ketanest i.v.

A

1-2mg/´kg Narkoseeinleitung

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12
Q

Dosierung Ketanest i.m.

A

5-10mg/kg

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13
Q

Dosierung Ketanest nasal/oral

A

6-10mg/kg

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14
Q

Dosierung Ketanest rektal

A

10mg/kg

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15
Q

Proteinbindung Etomidat

A

75%

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16
Q

Etomidat Verteilungsvolumen

17
Q

Etomidat HWZ Eliminierung

18
Q

Etomidat HWZ Verteilung

19
Q

Etomidat Metabolisierung

A

Esterhydrolyse

hepatisch

20
Q

Thiopental Proteinbindung

21
Q

Thiopental Verteilungsvolumen

22
Q

Thiopental HWZ Verteilung

23
Q

Thiopental HWZ Elminierung

24
Q

Thiopental Metabolisierung

A

Hepatisch zu Pentobarbital (lang wirksam) und Carboxylsäure

25
Nebenwirkung Etomidat
delta-aminolaevolinsäure - syntethase wird induziert Blockiert 17-a-hydroxylase und 11-beta-hydroxylase -\> inhibiert Corticosteron -\> Aldosteron und Hydrocortison

FCATDESA (14 decks)

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