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FCATDESA > Opiate > Flashcards

Opiate Flashcards

1
Q

Opiatrezeptoren

A

MOP - Sedation, respiratory depression
DOP - Spinal und peripher
KOP - Spinal und peripher
NOP - Belohnung und Gewöhnung

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2
Q

Wirkweise Opiate

A
  • inhibit intracellular adenyl cyclase via G protein- coupling, -hyperpolarize cell membranes by facilitating the opening of post- synaptic potassium channels
  • inhibit neurotransmitter release by decreasing the function of voltage-gated calcium channels.
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3
Q

Morphium Bioverfügbarkeit

A

100% (i.m.),
20–40% (oral),
35–70% (rectal)

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4
Q

Metabolisierung Morphium

A

Morphin-6-Glucorunid (15%, aktiv)

Morphin-3-Glucorunid

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5
Q

Fentanyl kontextsensitive HWZ

A

Infusion: 2h 48 min
8h: 282min

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FCATDESA (14 decks)

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