Pharmacy Review Flashcards
Who can prescribe prescription drugs
Require a written prescription by an accredited authorized
Prescriber provider.
What are controlled substance prescriptions written on
DD 1289
Define pharmacokinetic
the study of drug absorption, distribution, metabolism and excretion
What are factors that alter bioavailability?
Drug form, route, liver changes, GI mucosa, food and drugs, solubility
Where does metabolism occur?
Liver, kidneys, lungs, plasma, and intestinal mucosa
What factor can increase the half-life of a drug?
Liver disease and old age
What is a cumulative drug effect?
When the body has not fully metabolized a dose of a drug before the next dose is given.
What is an additive drug reaction?
When the combined effect of two drugs equal the sum of each drug given alone
What is synergism
When drugs produce an effect that is greater than the sum of their separate actions
What are the parenteral drug admin routes?
SubQ = between skin and muscle (slower than IM), IM = directly to the muscle, IV= directly into the blood (action is immediate), ID= first and second layer of the skin (sensitivity tests)
What can be applied to the skin causing a systemic effect?
transdermal
What route has a local effect on the lungs?
inhalation
In high doses, what drug has anticonvulsant properties?
Barbiturates
What is used as a short term antianxiety?
Benzodiazepines
What are some examples of benzodiazepines?
(END in PAM) Diazepam, Lorazepam, Alrazolam
What is used in the management of generalized tonic-clonic, status epilepticus and partial seizures?
Barbiturates
How do antidepressants work?
increase serotonin by inhibiting neuronal uptake to CNS
Who will not be prescribed MAOI?
CVA disease, CHF, Hypertension
How do antipsychotics work?
Block dopamine receptors in the brain
What is a contraindication of antipsychotics
Hypotension
What is an antipsychotic carried onboard
Haloperidol
What are CNS stimulants used for?
Treatment of ADHD and Narcolepsy
How do anticonvulsants work?
Reduction of excitability of the neurons in the brain
What are some examples of anticonvulsants?
(End in PAM) Diazepam, Lorazepam, Clonazepam
What is the adverse side effects of TCA’s?
Dry mouth, blurred vision, postural hypotension, urinary retention, constipation and orthostatic hypotension.
When used with a MAOI, what may result in a fatal reaction referred to as serotonin syndrome?
Setraline
What is the action of anti-emetics?
Primarily by inhibiting the chemoreceptor trigger zone or by depressing the sensitivity of the vestibular apparatus of the inner ear
Ondansetron block the effects of serotonin at what?
5-HT3 receptor sites
What are some examples of antiemetics and antivertigo?
(End in ZINE) Promethazine, meclizine
How does local anesthetics work?
inhibiting transport of ions across neuronal membranes
What is used in the relief of mild to moderate pain?
Non-salicylates
What is an example of non-salicylates?
Acetaminophen
What is the action of NSAIDS?
- Inhibit the action of cox1 and cox2 which is responsible for prostaglandin synthesis
What is the difference between COX1 and COX2?
Non-selective and Selective
What is a possible adverse side effect of NSAIDS?
GI upset and may increase your risk of heart attack or stroke
Long term use of NSAIDS may result in what
GI bleeding, stop use if prolonged bleeding or dark stools occur
What medication is both a salicylate and an NSAID?
Aspirin
What is the action of Narcotic Analgesics?
Alteration to the perception of and response to pain
What is the Antagonist to Narcotics (Opioids)?
Naloxone
What can antihistamines also be used to treat?
Insomnia, motion sickness, or vertigo
What are H2 antihistamines used to treat?
Gastric Ulcers
How do decongestants work?
induces vasoconstriction of the blood vessels in the nose, throat and paranasal sinuses, which results in reduced swelling and mucus formation in these areas
What is the max amount of time you can take Oxymetazoline HCL for?
no more than 3 days, may result in rebound congestion
How do Beta2 agonists work?
Cause relaxation (dialation) of bronchioles
What is a contraindication of beta2 agonist?
Cardiac arrhythmias, narrow angle glaucoma. Also should not be used while taking a beta blocker as it may inhibit the effects of the beta2 agonist
What are the adverse effects of anticholinergics?
Flushed face, Blurred vision, Urinary retention, Confusion, hallucinations, increased heart rate/body temp and dry mouth.
What is used in the treatment of Asthma and COPD?
Leukotriene antagonist and mast cell stabilizers
How do antitussives work?
Depress cough center and anesthetize stretch receptors
How does expectorants work?
Expectorants reduces the viscosity, tenacious secretion by increasing respiratory tract fluid
What loosens and mobilizes thick mucus from respiratory system?
Mucolytic
What is used as an expectorant on board?
Guaifenesin
What do antiarrhythmic do?
decreases symptomatology while increasing hemodynamic performance
What do class 2 beta blockers do?
Block stimulation of the beta receptors of the heart