Pharmacology Qs Flashcards
(53 cards)
What drug causes black tongue & stool? Final 2017, 2013, 2010, 2009, 2008
Bismuth subsalicylate
Why is concurrent administration of antacids and some other drugs not recommended? 2017
- Antacids can alter the absorption of other drugs
- Antacids can increase bicarbonate secretion
- Antacids can inhibit CYP 450 enzymes
- The combination can lead to increase in gastric acid secretion
- Antacids can alter the absorption of other drugs
Which of the following drugs can treat acid reflux and may cause galactorrhea and gynecomastia? 2017, 2016, 2015, 2014
- Dicyclomine
- Misoprostol
- Cimetidine
- Omeprazole
- Cimetidine
Which of the following is a H/K ATPase blocker on the apical surface of parietal cells? 2016, 2015, 2014, 2013, 2012, 2011, 2009
- Dicyclomine
- Misoprostol
- Cimetidine
- Omeprazole
- Omeprazole
A patient with duodenal ulcer presented with hematemesis, electrocautery was done to treat the ulcer. What will you administer at this stage? 2016
- Omeprazole
- Ranitidine
- Somatostatin
- Sucralfate
- Omeprazole
Which drug is used for peptic ulcers caused by NSAIDs? 2016, 2015, 2014, 2012
- Misoprostol
- Bismuth subsalicylate
- Misoprostol
Which of the following is contraindicated in pregnancy? 2016, Final 2014, 2010, 2009
- Promethazine
- Misoprostol
- Misoprostol
What is the rationale behind Quadruple therapy of peptic ulcer? Final 2015, Final 2014
- Reduce the cost
- Decrease fatal adverse effects
- Decrease emergence of resistance species
- Decrease drug-drug interactions
- Decrease emergence of resistance species
How does famotidine reduce the effect of sucralfate? 2015, 2014
- Inhibition of proton pump
- Inhibition of prostaglandin
- Induces CYP450
- Reduces the acidity of stomach
- Reduces the acidity of stomach
What is a drug that is considered cytoprotective for the gastric mucosa and is part of the treatment of H. Pylori? Final 2014, 2014, 2013, 2008
- Misoprostol
- Bismuth subsalicylate
- Dicyclomine
- Sucralfate
- Omeprazole
- Bismuth subsalicylate
What is the mechanism of action of dicyclomine? 2012
Muscarinic antagonist
A patient with epilepsy using phenytoin and he had peptic ulcer. Which drug should be avoided? 2012
- Omeprazole
- Famotidine
- Magnesium
- Misoprostol
- Omeprazole
How does ranitidine reduce the efficacy of sucralfate? Final 2011, 2010
It reduces the acidity of the stomach
What is the goal of triple therapy in treating peptic ulcer disease? 2011
To eliminate or reduce the occurrence of drug resistance
What cytoprotective drug is used for the treatment of h.pylori? 2010
- Bismuth chelate
- Sucralfate
-
How do antacids affect sucralfate efficacy? 2009
By altering pH in stomach
Why is a renal transplant patient on cyclosporine advised not to drink grapefruit juice? 2017, 2014, 2013, 2012
- It inhibits cyclosporine metabolism
- The dose of cyclosporine needs to be increased
- Increases the risk of organ rejection
- It inhibits cyclosporine metabolism
In terms of biotransformation, a phase II reaction described as: 2017, 2013
- Conjugation reaction
- Anaerobic reaction
- Hydrolysis reaction
- Oxidative phosphorylation
- Conjugation reaction
Which drug interacts with cyclosporine and enhances its metabolism resulting in organ rejection? Final 2015, 2011
Rifampicin
What is the mechanism of cimetidine? Final 2015, 2011, Final 2009
Inhibit CYP450 metabolism of other drugs
Which drug increases the synthesis of CYP450 enzymes? 2011
Rifampicin
A patient taking OCP, what do you advise her not to take with it? 2010
St. John’s worts
If diazepam and cimetidine are given together, what must be done? 2009, 2008
Reduce diazepam dose
What is the major oxidant in the liver? 2008
Cytochrome P450
