Pharmacology - Pain Management and Treatment of MSK Disorders Flashcards
most side effects of NSAIDs occur via inhibition of which enzyme
a.cox1
b.cox2
c.cox3
a.cox1
most anti inflammatory effects of NSAIDS occur via inhibition of which enzyme
a.cox1
b.cox2
c.cox3
b.cox2
which NSAID is used in pain and inflammation in MSK disease, post operatively and in dental pain
a.aspirin
b.paracetemol
c.ibruprofen
d.advil
e.diclofenac
c.ibruprofen
which NSAIDis is used for pain and inflammation in MSK disease, acute gout and post pain
a.aspirin
b.paracetemol
c.ibruprofen
d.advil
e.diclofenac
e.diclofenac
why should individuals over 60 not take primary preventative aspirin
risk of life threatening GI bleed
but over 60s with atherosclerosis should take secondary preventative aspirin
which drugs in combination with NSAIDs cause increased risk of GI bleeding
a.anticoagulants and antidepressants
b.ACEi/ARBs
c.diuretics
d.methotrexate
a.anticoagulants and antidepressants
which drugs do NSAIDS cause reduced efficacy in
a.anticoagulants and antidepressants
b.ACEi/ARBs
c.diuretics
d.methotrexate
b.ACEi/ARBs
can also cause kidney failure with ACEi
which drugs do NSAIDs cause reduced efficacy in
a.anticoagulants and antidepressants
b.ACEi/ARBs
c.diuretics
d.methotrexate
c.diuretics
which drugs in combination with NSAIDs cause increased toxicity especially if the other drug is used in cancer
a.anticoagulants and antidepressants
b.ACEi/ARBs
c.diuretics
d.methotrexate
d.methotrexate
what NSAID is appropriate for use in children
paracetamol and brufen
hypersensitivity reaction leading to erythema multiforme major
Steven johnson syndrome
contraindications of NSAIDs
PUD
ASPIRIN reyes syndrome
use with caution in pregnancy , especially 3rd trimester can close ductus arterioles in utero, retail impairment, hypertension, hypersensitivity reaction
anticoagulants contraindicated
corticosteroids used in MSK disease when ..
NSAIDs contraindicated
pud, poor renal function
what is used to relieve pain and stiffness in arthiritis
a.low dose prednisolone
b.high dose prednisolone
c.beclomethasone
d.methotrexate
a.low dose prednisolone
what is used for severe flare ups in arthiritis
a.low dose prednisolone
b.high dose prednisolone
c.beclomethasone
d.methotrexate
b.high dose prednisolone
what effects do steroids have on large doses of opioids
a.reduce the risk associated
b.increase the risk associated
reduce risk associated with large doses of opioids
DMARDs examples
methotrexate leflunomide
key points about DMARDs
longer onset of action 4-6 weeks
affect underlying cause of disease
care with adverse effects
extreme caution in female patients due teratogenic effects
Biological DMARDs should only be considered when
after specialist assessment and advice from a rheumatologist
True or false DMARDs can be started at the same time as NSAIDs
true
good as DMARDs take 4-6 weeks before effects seen
what is used as an manager of acute gout attacks
a.methotrexate
b.diclofenac
c.colchine
d.allopurinol
c.colchine
gout presentation
hot red big toe
which of these drugs is an inhibitor of microtubules in neutrophils and is used for acute gout attacks
a.colchine
b.allopurinol
c.methotrexate
d.leflunomide
e.denosumab
a.colchine
which of these drugs is a inhibitor of xanthine oxidase and is used in management of long term gout to decrease uric acid levels
a.colchine
b.allopurinol
c.methotrexate
d.leflunomide
e.denosumab
b.allopurinol
osteoarthritis symptoms
pain
swelling
loss of function
pain management for osteoarthritis
exercise ans therapy, weight loss , TENS
paracetamol NSAIDS, PPI given with this and opioids
imtraarticular steroid injection eg triamcinolone
