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Step 1 Review > Pharmacology One-liners 3 > Flashcards

Pharmacology One-liners 3 Flashcards

1
Q

Iron-chelator that is used to protect against anthracycline-induced cardiotoxicity

A

Dexrazoxane

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2
Q

DNA intercalating agent useful for treatment of solid tumors in children

A

Dactinomycin (actinomycin D)

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3
Q

DNA intercalating agent with minimal myelosuppression that induces formation of free radicals; dose-limiting side effects include pulmonary fibrosis and mucocutaneous reactions

A

Bleomycin

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4
Q

Antineoplastic with G2 phase cell cycle selectivity

A

Bleomycin

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5
Q

Ribonucleotide reductase inhibitor with S phase cell cycle selectivity that is used for management of sickle cell anemia

A

Hydroxyurea

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6
Q

Platinum-derivatives that form DNA intrastrand cross-links; causes dose-limiting nephrotoxicity and ototoxicity

A

Cisplatin, carboplatin

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7
Q

Two antineoplastics that inhibit topoisomerase I

A

Irinotecan, topotecan

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8
Q

Two antineoplastics that inhibits topoisomerase II

A

Etoposide, teniposide

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9
Q

Inhibits BCR-ABL tyrosine kinase expressed by the Philadelphia chromosome in chronic myeloid leukemia

A

Imatinib

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10
Q

Inhibits BRAF kinase in melanomas with BRAF V600E mutation

A

Vemurafenib

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11
Q

Chimeric monoclonal antibody against CD20 antigen found on non-Hodgkin lymphomas and normal B lymphocytes

A

Rituximab

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12
Q

Recombinant human monoclonal antibody against vascular endothelial growth factor (VEGF)

A

Bevacizumab

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13
Q

Recombinant human monoclonal antibody against human epidermal growth factor-2 (HER-2) receptor; useful for breast cancer cells that overexpress HER2

A

Trastuzumab

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14
Q

Gonadotropin-releasing hormone agonist that can be used to inhibit luteinizing hormone secretion and testosterone production in men with advanced prostate cancer

A

Leuprolide

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15
Q

Two most commonly used glucocorticoids for cancer due to their lymphotoxic effects; may cause Cushing-like symptoms

A

Prednisone, prednisolone

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16
Q

Increase activity of cytotoxic cells and indicated for hairy cell leukemia

A

Interferon alpha-2b

17
Q

Agent used for hypochromic microcytic anemias

A

Ferrous sulfate

18
Q

Agent used for megaloblastic anemia (but does not reverse neurologic symptoms) and decrease neural tube defects during pregnancy

A

Folic acid

19
Q

Agent used for megaloblastic anemia with neurological deficits

A

Vitamin B12

20
Q

Agent used for pernicious anemia

A

Cyanocobalamin (Vit B12)

21
Q

Agent used for anemias (especially with renal failure)

A

Erythropoietin

22
Q

Agent used for neutropenia associated with cancer chemotherapy and bone marrow transplantation

A

Filgrastim (granulocyte colony stimulating factor) and sargramostim (granulocyte-macropahge colony-stimulating factor)

Step 1 Review (6 decks)

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