Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

NeuroPsych > Pharmacology of Schizophrenia > Flashcards

Pharmacology of Schizophrenia Flashcards

1
Q

DA Receptor Blockade: Efficacy vs Toxicity

A

Need >60% D2 blockade for efficacy

>80% = EPS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What is the relationship between FGA potency and prominent side effects?

A

Low potency = anticholinergic and antihistaminergic effects

High potency = EPS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What drug interactions do you need to keep in mind with FGAs?

A

CYPs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Which SGAs may attenuate TD sx?

A

Seroquel and Clozapine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What does the BBW for clozapine say?

A

Agranulocytosis
Seizures
Cardiac complications

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Important side effects with clozapine

A 
Hypotension
Bowel Obstruction
Sedation
Weight gain
Metabolic side effects
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Clozapine Titration

A

Slow
If miss 2 doses, must start titration from beginning
Nicotine lowers clozapine levels
12.5-25mg then increase by 25mg daily to target dose between 300mg

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Goal WBC and ANC

A 
WBC: >3.5
ANC: >2
Weekly for 6 months
Then every 2 weeks for 6 months
Then Every 4 weeks forever
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Clozapine Registry Guidelines

A

WBC 2-3/ANC 1-1.5 = interrupt therapy, wait then rechallenge

WBC<1 = d/c and do not rechallenge

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Risperidone

A

Most “typical”
Highest EPS of SGAs
Hypotension

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Olanzapine

A

Highest metabolic side effects and wt gain (w/ clozapine)

Smoking lowers levels

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Seroquel

A

May improve TD

SEDATION and weight gain

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Ziprasidone

A

500 calories of food + BID
Activating at low doses
Affects NE and SR too

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Abilify

A

Partial agonist
Best side effect profile
Akathisia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Paliperidone

A

Similar to risperidone and similar side effects

ER capsule found in stool

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Saphris (asenapine)

A

Sublingual

17
Q

Lurasidone

A

Great side effect profile minus sedation

MUST be taken with food

18
Q

LAIA

A

There are several LAIAs to improve compliance
Most every 2-4 weeks
Deltoid or gluteal administration

19
Q

Risperidone LAIA

A

Bridge with oral therapy for 3 weeks

20
Q

Invega

A

First 2 doses should be deltoid (fear of needles - don’t do)

21
Q

Zyprexa LAIA BBW

A

Post injection delirium

Monitor for 3 hours after injection!

22
Q

Abilify LAIA

A

Oal overlap for 2 weeks

23
Q

Akathisia Treatment

A

Lower dose, but if stable on that dose give propranolol

24
Q

Screening Tool to Test for TD

A

AIMS

Abnormal Involuntary Movement Scale

25
Q

SGAs with worst metabolic side effect profile

A

Olanzapine and Clozapine

26
Q

Hyperpolactinemia

A

FGAs and risperidone are the WORST

Add Abilify or bromocriptine

27
Q

Drooling

A

Most common with clozapine

Ipatropium NS and atropine eye drops SL

NeuroPsych (13 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions