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NeuroPsych > Mood Disorders > Flashcards

Mood Disorders Flashcards

1
Q

Major Depressive Episode

A

5+ sx in same week and change in functioning

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2
Q

Persistent Depressive Disorder

A

Depressed mood + 2 sx >1 year

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3
Q

Bipolar Disorder/Manic Depression

A

3+ sx greater or equal to 1 week

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4
Q

MAO hypothesis

A

Low monoamines DA, NE, SR

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5
Q

Dysregulation hypothesis

A

Dysregulation of postsynaptic receptors due to abnormal neurotransmitter concentrations

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6
Q

Neuroendocrine hypothesis

A

Hypothyroidism and dysfunctional HPA axis (high cortisol levels but limited stress response to dex challenge)

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7
Q

Key components of antidepressant pharmacology

A

Alleviate depressive sx, not CNS stimulant
Neurostransmitter levels increase rapidly, but sx not reduced for weeks
Sudden d/c = rapid withdrawal sx

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8
Q

Measuring Response/Onset of Effects

A

Week 1: appetite, sleep,
Weeks 2-3: drive and concentration
Weeks 4-6: mood and hopelessness

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9
Q

Best indicator of clinical response?

A

Fatigue

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10
Q

How long is an adequate trial of antidepressants?

A

8 weeks

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11
Q

TCAs Side Effects

A

Hypotension/increased HR - alpha
Wt gain - His
Lower seizure theshold - GABA
AntiAch - m

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12
Q

TCAs MOA

A

Block reuptake of NE and SR

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13
Q

MAOi MOA

A

Block degradation of NE, SR and DA

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14
Q

Selective vs Non-Selective MAOis

A

MAOa and MAOb

Selegiline - MAOb only - less dietary restrictions

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15
Q

MAOi Drug Interaction

A

Tyramine! - HTN crisis

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16
Q

Serotonin Syndrome

A 
Abdominal pain
High HR and BP
Changes in MS
Tremor
Diarrhea
17
Q

SSRI Side Effects

A

GI upset
Stimulant (paxil - sedation)
Weight loss
Low libido

18
Q

SSRI Withdrawal

A

Flu like syndrome

TAPER

19
Q

NDRI

A

Wellbutrin

DA > NE&raquo_space;»»»> SR reuptake blockers

20
Q

SNRI

A

SR NE Reuptake Inhibitor

21
Q

SARI

A

SR antagonist and reuptake inhibitor!

Trazodone

22
Q

NSSA

A

Noradrenergic Specific Serotonin Antidepressant
Mirtazapine
Increases neurotransmitter levels
Anti-histamine activity = sedation and weight gain

23
Q

Drugs use to augment antidepressants

A 
Lithium
Pindolol
Stimulants
Atypical Antipsychotics
Synthroid
Anticonvulsants

NeuroPsych (13 decks)

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