Anxiety Flashcards
Who is most at risk of anxiety?
Women
Whites
30-40s
Anxiety Rating Scales
HAM-A
SAS
STAI
GAD Dx Criteria
General anxiety for >6 months + 3 of 6 other sx (fatigue, restless, irritable, pain etc)
Distress/impairment
First Line Treatment of GAD
SSRIs - start at 1/2 dose to avoid rebound anxiety
Reassess after 4 week trial
SSRI Side Effects
GI upset - goes away
Loss of libido
Weight gain
SR Syndrome
Which SNRIs are first line for GAD?
Duloxetine and Effexor XR
Hi doses = NE activity
Second Line GAD
TCAs BZDs Buspirone Lyrica Vistaril Benadryl
TCA Side Effect Profile
Cardiac complications
Suicide
Anti-Ach effects!
BZDs in GAD
Not recommended as mono therapy - dependence/tolerance
Require GABA to be bound, to have effect!
Which BZDs have active metabolites?
Chlordiazepoxide - oldest
Diazepam
Which BZD has the worst withdrawal effects?
Oxazepam
Which BZDs can be given in hepatic dysfunction?
Lorazepam
Oxazepam
Temazepam
Not metabolized by p450s!
Short and Long Term Considerations in BZDs in GAD
Short - rebound anxiety
Long - amnesia, dependence
Stopping BZDs
Taper by 10% every 2-3 weeks and monitor for GAD/withdrawal sx
Buspirone
SR autoreceptor blockers
Onset 4-6 weeks
Lyrica in GAD
Basically 3rd line because not a thing
Not robust enough evidence
Anti-His in GAD
Sedation purposes only
NOT for severe GAD
PRN/adjunct
Panic Disorder w/o Agoraphobia Dx Criteria
Panic attacks + 1+ months of worrying about attacks (future occurrences, implications, ∆behavior)
PD w/ Agoraphobia Dx Criteria
Panic attacks + 1+ months of worrying about attacks (future occurrences, implications, ∆behavior)
PLUS
Anxiety of being in place where escape is impossible/embarrassing - avoided or endured w/ distress
Who had PD commonly?
Women
MDD
Alcohol Dependence
Which SSRIs have the worst d/c syndrome?
Paroxetine
Cymbalta
Effexor
Panic Disorder First Line
SSRIs
Panic Disorder Second Line
SNRIs - effexor XR only (IR - somatic sx, anxiety issues)
BZDs
TCAs
Social Phobia
INTENSE fear of social/performance sitch - humiliation/embarrassment
Insight
If 6 months
Social Phobia Treatment
SSRIs - not Paxil even though it was the first one to be approved by FDA
Effexor XR (2nd line)
BZDs - adjunct to SSRIs
Propranolol