Pharmacology of Psychedelics and Psychoactive inhalants Flashcards
What are psychedelics
are agents that produce non- ordinary and variable forms of conscious experiences. These include changes in mood, thoughts, and distorted perceptual sensations generally only experienced in dreams
What is a delusion?
A. a false perception arising from internal stimuli that creates a false reality
B. Fixed false belief unresponsive to logic; paranoi is common
C. A misperception of external stimuli. distorts reality
B.
What is a hallucination?
A. a false perception arising from internal stimuli that creates a false reality
B. Fixed false belief unresponsive to logic; paranoi is common
C. A misperception of external stimuli. distorts reality
A
What is an Illusion
What is a hallucination?
A. a false perception arising from internal stimuli that creates a false reality
B. Fixed false belief unresponsive to logic; paranoi is common
C. A misperception of external stimuli. distorts reality
C.
What are dissociative psychedelics. select all that apply
A. Phencyclidine
B. derivates of tryptamine
C.Derivatives of phenethylamine
D. Ketamine
E.Muscimol
F.Dextromethorphan
A,D,E,F
What are the classical psychedelics
derivatives of phenethylamine and derivatives of tryptamine
What are the derivatives of phenethylamine?
Mescaline,MDMA, MDA
What are the derivatives of tryptamine
DMT, LSD, and psilocybin
Mescaline MOA
Increase release of 5-HT> DA, NE
lowest potency, long lasting, cross tolerance to LSD
What are the naturally occurring clasical psychedelics
5-MEODMT (from toad) and psilocybin (mushroom)
What are classical psychedelics agonists of
5-HT2a receptors
pre-tx with 5-HT2A antagonists blocks the psychedelic effect
exception MDMA stimulates 5-HT release
What do psychedelics effect
Visionary restructuralization (sensory illusions), oceanic boundlessness (highly pleasurable state of self-dissolution), thought disorder lead to bad trip
What are the short term physiological AE of psychedelics
tachycardia, HTN, tremors, dry mouth,Nausea, hyperthermia
what are the acute dysphoric reaction of psychedelic drugs
terrifying thoughts fear of insanity fear of losing control fear of death
What is a psychotic reaction from psychedelics
Flashbacks, enduring changes, exacerbate underlying psych disorder, instigate prolonged psychotic disorder, rate psychosis after LSD 1 to 5%
What are the potential therapeutic uses of psychedelics
cancer related psychological distress
PTSD
Depression
Substance use disorder
T or F: dissociative psychedelics act as antagonists of NMDA receptors
T
What are the prominent NMDA receptor antagonists
inotropic glutamate receptors, ketamine, dextromethorphan
What are inotropic glutamate receptors
NMDA receptor antagonist
induce anesthesia and analgesia
T or F: the S enantiomer of ketamine is less active
F it is more active
T or F: Dextromethorphan is primarily abused by highschoolers
T
abuse doses 100-600mg
T or F: PCP is more potent then ketamine
T
PCP is a agonist of which neurotransmitter
D2
what is muscimol an agonist of
GABAa
