Pharmacology of Cannabis-Cannabinoids Flashcards
marijuana legalization
1937: congress passes Marijuana tax act
1996: california passes prop 215 becoming first legal medical marijuana state
2013: cole mem creates hands off policy for legal medical marijuana states
cannabis remains schedule 1 under federal controlled substance act
Describe the clinical effects associated with cannabis ingestion
perceptual affective physical and cognitive effects
Name the 4 key components of the endocannabinoid system and where ∆ 9−THC acts on this system
receptors, ligands, transporter and enzymes
THC is a partial agonist at CB1 receptor
Summarize the association of heavy cannabis use with mental health disorders
extremely difficult to prove and controversial growing evidence for association with several disorders cause and effect not established
Describe the symptoms of cannabinoid hyperemesis syndrome
cyclic vomiting/abdominal pain presentation after prolonged excessive use relief by sustained cessation may be associated with pathological bathing(hot shower/bathing)
What is marijuana
dried leaves and flowers
What is Hashish
compressed stalked resin glands from cannabis flower blossoms
What is the THC level of Hemp
A. <0.1
B.<0.2
C. <0.3
D. < 0.4
C. 0.3% or less
hemp is grown for agricultural products such as textiles seeds and oils
What is the THC levels in marijuana
A. 10-20%
B. 15-20%
C. 20-30%
D. 30-40%
B
HEMP leagalization status
2014 president obama signs farm bill allowing hemp to be cultivated for research purposes
2018: Farm bill passes federally legalizing hemp-derived products including CBD oil
What are the perceptual effects of acute canabis intoxication
temporal slowing auditory visual or tactile illusions de-personalization
What are the affective effects of acute canabis intoxication
euphoria, disinhibition, anxiety emotional lability
What are the physical effects of acute canabis intoxication
Tachycardia
Postural hypotension
Conjunctival injection
Dry mouth
Increase appetite
What are the cognitive effects of acute canabis intoxication
Suspiciousness or paranoid ideation
Impaired judgement
Impaired reaction time
Impaired attention
What is the ECS
widely distributed in the CNS comprised of receptors(CB1 &2),ligands (anandamine and 2-AG), transporters (EMT), and enzymes (FAAH,MAGL, and DAG)
What two substances serve as retrograde regulators of neurotransmission inhibiting release of GABA and glutamine
Endocannabinoids and Phytocannabinoids
T or F: THC is a partial agoinst at CB1R while synthetic cannabinoids are full agonists
T
T or F: CB2 receptor expression is higher than CB1 expression in the brain
F: CB1 expression is higher
T or F: CB1 low levels respiratory centers of brainstem causing <resp.depression and coma
T
T or F: CB2 expression in periphery is higher than CB1 receptor expression
T
CB2 has role with lymphoctes B and T cells
what does CB1 have a role in
the liver increase lipogenesis and upregulation in liver fibrosis
What is marinol (dronabinol)
A FDA approved cannabinoid
synthetic THC in sesame oil
schedule 3
counter loss of appetite
tachycardia and red eyes
What is Nabilone (Cesamet)
THC mimetic
* Schedule II
* Anti-emetic
* Chronic pain (Off Label)
* Fibromyalgia
* Multiple Sclerosis
What are the challenges associated with medical marijuana use
Lack of product quality control
Absence of adequately designed studies for assessing efficacy and
ADR
Highly politicized environment precludes a rational approach
Growing influence of big tobacco and alcohol industries in cannabis industry
