Pharmacology of Oral Hepatitis C Therapies

Question 1

What family of viruses is HCV in?

Answer 1

Flaviviridae

Question 2

What type of virus is HCV?

Answer 2

ssRNA enveloped

Question 3

What type of virus is HBV?

Answer 3

dsDNA-RT

Question 4

Name a treatment for hepatitis C

Answer 4

Pegalyted IFN alpha-2a or alpha 2b with ribavirin

Question 5

What type of analogue is ribavirin?

Answer 5

nucleoside

Question 6

Name a NS3/4A serine protease inhibitor

Answer 6

Faldaprevir

Question 7

Describe the first wave of NS3/4A serine proteases.

Answer 7

Linear peptide-mimetics with an alpha-ketoamide group that binds covalently but reversibly to Serine on the enzyme active site
Potent antiviral activity on HCV genotype 1

Question 8

Describe the second generation of NS3-4A serine protease.

Answer 8

Linear non-covalent peptidomimetic inhibitors

Question 9

Describe the third generation NS3/4A serine proteases.

Answer 9

macrocyclic non-covalent peptidomimetic inhibitors

Question 10

Name a non-nucleoside inhibitor (NS5B inhibitor)

Answer 10

Dasabuvir

Question 11

Name a nucleoside/nucleotide inhibitor (NS5B inhibitor)

Answer 11

Sofosbuvir

Question 12

Name NS5A inhibitors.

Answer 12

Daclatasvir, ledipasvir, ombitasvir

Question 13

Name some inhibitors of CYP3A4

Answer 13

Glecaprevir, voxilaprevir, grazoprevir, paritaprevir (all NS3/4A protease inhibitors