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Pharmacology > Pharmacology of Inflammation > Flashcards

Pharmacology of Inflammation Flashcards

1
Q

increase vascular permeability, bronchoconstriction

A

leukotrienes

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1
Q

prostaglandins class

A

lipid mediators

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2
Q

increased extracellularly during injury: anti-inflammatory, inhibit cytokine action

A

adenosine

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2
Q

glucocorticoids cellular source

A

adrenal cortex

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3
Q

bradykinin cellular source

A

endothelial cells

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4
Q

bradykinin class

A

peptide

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4
Q

Oxygen-derived free radicals class

A

superoxide, hydroxy radicals

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5
Q

vasodilation, pain, fever, platelet aggregation (via thromboxane)

A

prostaglandins

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5
Q

cell adhesion molecules mechanism

A

contact molecules, calcium dependent

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6
Q

prostaglandins mechanism

A

activation of specific GPCRs

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7
Q

adenosine cellular source

A

all cells

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7
Q

leukotrienes mechanism

A

activation of GPCRs

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8
Q

glucocorticoids class

A

lipid mediators

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9
Q

prostaglandins cellular source

A

virtually all cells

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10
Q

complement system cellular source

A

synthesized by liver, circulate in blood

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11
Q

C-reactive protein class

A

plasma proteins

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12
Q

Histamine cellular source

A

mast cells, basophils

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13
Q

complement system mechanism

A

complement protein complexes cause osmotic lysis activation of GPCRs

14
Q

C-reactive protein cellular source

A

produced in liver in response to cytokines, also produced in adipocytes

15
Q

cell adhesion molecules cellular source

A

endothelial cells, platelets, leukocytes

16
Q

leukotrienes cellular source

A

macrophages, neutrophils

17
Q

cytokines mechanism

A

bind to specific receptor proteins to induce gene expression of number of proteins via activation of Nf?B and AP-1; increase COX (fever) and lipoxygenases, increase adhesion molecule expression, induce collagenase (fibrosis)

19
Q

inhibition of cytokines, inhibition of phospholipase A2, inhibition of COX-2, inhibition of cell adhesion molecules

A

glucocorticoids

21
Q

vasodilation, increased vascular permeability, pain

22
Q

cytokines class

A

secreted proteins, in particular the pro-inflammatory cytokines: Interleukin-1 (IL-? & IL-?) and TNF-?

24
Q

vasodilation, increased microvessel permeability, pain

A

bradykinin

25
Q

cell adhesion molecules class

A

family of proteins

26
Q

histamine class

A

biogenic amine

27
Q

Acute-phase reactant, activates complement cascade, mediates phagocytosis, marker of inflammation

A

C-reactive protein

28
Q

Histamine mechanism

A

activation of GPCRs

29
Q

adenosine mechanism

A

activation of GPCRs

31
Q

cytokines cellular source

A

nearly all inflammatory cells

32
Q

glucocorticoids mechanism

A

activation of nuclear receptors

33
Q

intracellular killing of bacteria by neutrophils

A

Oxygen-derived free radicals

34
Q

chemotaxis, promote release of mediators from neutrophil, increase vascular permeability, excessive activation may contribute to tissue injury

A

complement system

35
Q

Oxygen-derived free radicals cellular source

36
Q

Oxygen-derived free radicals mechanism

A

protein oxidation, lipid peroxidation, DNA mutations

37
Q

leukocyte adhesion to endothelium is a pivotal event in host defense and tissue repair, endothelial adhesion molecules contribute to recruitment of activated platelets

A

cell adhesion molecules

38
Q

bradykinin mechanism

A

activation of GPCRs

40
Q

TNF-?: acute phase reaction, fever, sepsis; IL-1: acute phase reaction, fibroblast, and lymphocyte proliferation, fever

41
Q

leukotrienes class

A

lipid mediators

42
Q

adenosine class

A

purine nucleoside formed from breakdown of ATP

43
Q

complement system class

A

plasma proteins

44
Q

C-reactive protein mechanism

A

bind to phospholipids in bacteria and damaged cells may be specific receptors in macrophages

Pharmacology (9 decks)

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