Neuropsychopharmacology

Question 1

Dopamine pathways in the brain include:

Answer 1

1. Nigrostriatal
2. Tubero-infundibular
3. Mesolimbic
4. Mesocortical

Question 2

GABA localization:

Answer 2

1. Substantia nigra
2. Globus pallidus
3. Hippocampus
4. Limbic structures
   
   • Amygdala
   • Hypothalamus
   • Spinal cord

Question 3

Half life of duloxetine

Answer 3

12-18 h

Question 4

Use with caution in pt’s with liver disease

Approved for use in fibromyalgia, diabetic neuropathy, back pain, and osteoarthritis pain

Answer 4

duloxetine

Question 5

blocks norepinephrine and dopamine uptake

Answer 5

bupropion

Question 6

plasma half life of tricyclic antidepressants

Answer 6

8-100 hours

Question 7

drug interactions of tricyclic antidepressants

Answer 7

guanethidine - blocks guanethidine uptake

sympathomimetic drugs - particularly indirect acting ones

effects on absorption and metabolism of other drugs

Question 8

causes enuresis

Answer 8

tricyclic antidepressants

Question 9

which drugs interact with tyramine from food to produce hypertensive effects?

Answer 9

MAO inhibitors

Question 10

may progress to hypomania, particularly in bipolar disease

Answer 10

MAO inhibitors

Question 11

dopamine receptors that activate adenylyl cyclase

Answer 11

D1 type (D1 and D5)

Question 12

dopamine receptors that inhibit andenylyl cyclase

Answer 12

D2 type (D2, D3, D4)