Pharmacology Of Androgens And Anti Androgens

Question 0

What happens if there’s a deficiency of 5 alpha reductase?

Answer 0

Testes develop without prostrate

External genitalia resembles those of females

Question 1

What does testosterone do?

Answer 1

Gonadotrophin regulation
Initiates and maintains spermatogenesis
Sexual differentiation –> wolffian duct stimulation

Question 2

Clinical use of testosterone?

Answer 2

Delayed puberty
Primary hypogonadism in adductor males
Promotes erythropoiesis

Question 3

What can be used to treat prostate cancer?

Answer 3

Cyproterone acetate –> inhibit peripheral androgen receptors
GnRH analogues (goserelin and buserelin) –> suppress Leydig cell
GnRH antagonist (cetrorelix and ganirelix) –> regression of Leydig cell
Oestrogen

Question 4

How to treat benign prostate hypertrophy?

Answer 4

Alpha blockers - tamsulosin, alfuzosin –> act to relax smooth muscle component of prostate
5 alpha reductase blocker - finasterine (inbihit type 2) –> shrinkage of prostate