Pharmacology (Locals) Flashcards
Locals are drugs that produce a ___ interruption of neural impulses along __ and ___ pathways.
- Reversible
- sensory
- Motor
A nerve membrane is composed mostly of
biphospholipids with NA+ channels
nerve membranes are found where in unmyelinated nerves?
all throughout
nerve membranes are found where in myelinated nerves?
nodes of Ranvier
How many nodes are Ranvier need to be blocked to inhibit nerve transmission
2 successive nodes
What nerve fibers are commonly effected first?
B fibers
Type B Fibers
- Function
- Diameter
- Myelinated?
- Conduction velocity
- Pregangloinic autonomic
2.
A fiber Alpha function
proprioception & motor
A fiber Beta function
Touch & pressure
A fiber Gamma function
muscle spindles
Will local anesthetics have any impact on closed ion channels?
No, they do not work when channels are closed
Where do locals prevent neural action?
Prevent the opening of NA+ channels, thereby preventing the membrane potential from reaching threshold potential.
H gate?
Where locals are inactivated
Most commonly administered Ester Local?
Procaine (Novocaine)
What do ester locals yeild?
PABA
What is PABA? Why can it be a problem?
Para-amnio benzoic acid - is excreted UNCHANGED in the urine.
Is responsible for most producing most allergic reactions with Esters
Are there Esters in the CSF?
No