Hemostatis

Question 1

What is the only acceptable clinical indication for transfusion of packed red cells?

Answer 1

To increase carrying capacity of the blood

Question 2

What procoagulants are present in FFP?

Answer 2

ALL except for platelets

Question 3

What does cryo contain?

Answer 3

Factor I, 8 (both C and vWF), and 13. (cryo comes from thawing FFP)

Question 4

One unit of RBCS will increase HCT how much?

Answer 4

approximately 3-4% or 1g/dL

Question 5

1 cc/kg of RBCs will increase Hct how much?

Answer 5

1%

1 cc/kg = 1% hct

Question 6

One unit of platelets increases platelet count how much?

Answer 6

5,000 - 10,000/mm3

Question 7

What is defintion of massive transfusion

Answer 7

1 complete blood volume transfused within 24 hours.

Question 8

What is most common reason a patient is unresponsive to heparin?

Answer 8

Antithrombin deficiency

Question 9

What level must a patients ACT be at to be considered adequately heparinized?

Answer 9

ACT of 400

Question 10

If patient is not adequately heparinized, what should you do?

Answer 10

Give FFP, FPP contains all coagulation and all anticoagulant factors made by the liver, INCLUDING antithrombin (which is what heparin binds to)

Question 11

What pathway(s) does heparin work on?

Answer 11

Intrinsic and COMMON pathway

Question 12

Protamine reverses heparin how?

Answer 12

neutralization reaction.

Question 13

What are the Vit K dependent factors?

Answer 13

II, VII, IX, and X.

Question 14

Extrinsic pathway factors?

Answer 14

III, and VII (37 cents)

Question 15

Intrinsic pathway factors ?

Answer 15

XII, XI, IX, and VIII (12, 11.98)

Question 16

Common pathway?

Answer 16

V, X, I, II, and XIII

5 and Dime for 1 or 2 dollars on the 13th of the month

Question 17

Normal ACT time?

Answer 17

80-150

Question 18

Normal Fibrinogen level

Answer 18

> 150 mg/dL

Question 19

normal PT

Answer 19

12-14 seconds

Question 20

normal PTT

Answer 20

25-35

Question 21

normal platelet count?

Answer 21

150 - 400 thousands cells/mL

Question 22

Where is tPA made? (stimulated by thrombin and venous stasis)

Answer 22

Endothelial cells

Question 23

Most common cause of coagulatopathy in patients receiving massive blood transfusion is what?

Answer 23

Lack of functioning platelets