Pharmacology

Question 1

Competative reversal antagonists

Answer 1

Whoever brings the most guys to the fight wins!

NE vs Propranolol

They have WEAK bonds

Question 2

Competative Irreversible

Answer 2

for a STRONG bond - Once its stuck, its stuck!

Ex: Phenoxybenzamine (a1 antagonist)

Question 3

Zero order kinetics? Example?

Answer 3

Constant AMOUNT of drug

Important Examples are Phenytoin, salicylate, theophylline, thiopental, and of course Ethanol!!!

This implies metabolic saturation.

Question 4

First Order Kinetics

Answer 4

First = Fraction

The amount metabolized is directly proportional to drug volume.

This is the MOST COMMON way most medications are metabolized.

Question 5

What are the most important highly protein bound drungs?

Why is this important to know?

Answer 5

Phenytoin, Coumadin, diazepam, propranolol

since they competitively compete for receptors and are mostly protein bound, administering two of these drugs simultaneously will greatly increase FREE drug.