Pharmacology Lecture 4

Question 1

classical genetics

Answer 1

abnormal genes
lead to abnormal gene product
lead to disease

Question 2

kinds of risk factor

Answer 2

hereditary or environmental

Question 3

high genetic vulnerability disorders

Answer 3

schizophrenia

bipolar

Question 4

lower genetic vulnerability disorders

Answer 4

depression
anxiety
OCD

Question 5

excitotoxicity

Answer 5

too much excitation leading to neuron death
e. g. glutamate overactivity
too much calcium influx, which is neurotoxic

Question 6

excitotoxicity disorders

Answer 6

epilepsy
psychosis
panic disorders

Question 7

disorders with too little neurotransmission

Answer 7

Parkinson
Huntington’s (?)
Alzheimer

Question 8

parenteral

Answer 8

directly to the blood stream

Question 9

“GABA excites”

Answer 9

GABA does more of its usual thing, which is inihiting

Question 10

average signal cascade to reach early genes

Answer 10

three to four messengers

Question 11

average signal cascade to reach late genes

Answer 11

five to six messengers

Question 12

ion channel types

Answer 12

ligand-gated or voltage-gated

Question 13

ligand-gated

Answer 13

neurotransmitter attaches

Question 14

7 transmembrane

Answer 14

g protein

Question 15

12 transmembrane

Answer 15

all transporters

Question 16

p