Pharmacology Lecture 2 Flashcards
alpha phase
distribution half-life
beta phase
elimination half-life
amines
5HT
NE
DA
Ach
amino acids
glutamate
GABA
glutamate effect
stimulating
GABA effect
inhibiting
god’s pharmacopeia
body has its own drugs and receptors
co-transmission
usually the case
something other than the neurotransmitter is transported into the cell as well
allosteric modulation
changes the effect a neurotransmitter is already having
transport speed of neurotransmitters
very fast for glutamate and GABA, in milliseconds
slower, up to seconds for monoamines and neuropeptides
neuropeptides
signalling between cells
in synapses
only chemically
classical neurotransmission
electrical impuls in presynaptic
chemical message through cleft
= excitation-secretion coupling
retrograde neurotransmission
postsynaptic is talking back to presynaptic
three primary transmitters that do retrograde transmission
endocannabinoids
nitric oxide
neurotropic factors
vol me transmission
over larger distance
not via synapse
via puffs
binds to any matching receptors in diffusion distance
examples volume transmission
dopamine in cortex
monoamine autoreceptors
signal transduction cascade
presynaptic genome to posynaptic genome
early and late genes
first and last to be activated
two ways of transmission
G protein linked and ion channel linked
G protein linked cascade
1st messenger: neurotransmitter
2nd: G protein
3rd: enzyme, phosphorylating something
4th: transcription factors
ion channel linked system
1st messenger: neurotransmitter
2nd: outflowing calcium
3rd: enzyme
4th: transcription factors
G protein and ion channel linked overlap
can lead to the same gene expression
polymerase
opens DNA strand
