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Psychopharmacology > Pharmacology Lecture 2 > Flashcards

Pharmacology Lecture 2 Flashcards

1
Q

alpha phase

A

distribution half-life

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2
Q

beta phase

A

elimination half-life

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3
Q

amines

A

5HT
NE
DA
Ach

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4
Q

amino acids

A

glutamate

GABA

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5
Q

glutamate effect

A

stimulating

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6
Q

GABA effect

A

inhibiting

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7
Q

god’s pharmacopeia

A

body has its own drugs and receptors

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8
Q

co-transmission

A

usually the case

something other than the neurotransmitter is transported into the cell as well

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9
Q

allosteric modulation

A

changes the effect a neurotransmitter is already having

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10
Q

transport speed of neurotransmitters

A

very fast for glutamate and GABA, in milliseconds

slower, up to seconds for monoamines and neuropeptides

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11
Q

neuropeptides

A
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12
Q

signalling between cells

A

in synapses

only chemically

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13
Q

classical neurotransmission

A

electrical impuls in presynaptic
chemical message through cleft
= excitation-secretion coupling

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14
Q

retrograde neurotransmission

A

postsynaptic is talking back to presynaptic

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15
Q

three primary transmitters that do retrograde transmission

A

endocannabinoids
nitric oxide
neurotropic factors

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16
Q

vol me transmission

A

over larger distance
not via synapse
via puffs
binds to any matching receptors in diffusion distance

17
Q

examples volume transmission

A

dopamine in cortex

monoamine autoreceptors

18
Q

signal transduction cascade

A

presynaptic genome to posynaptic genome

19
Q

early and late genes

A

first and last to be activated

20
Q

two ways of transmission

A

G protein linked and ion channel linked

21
Q

G protein linked cascade

A

1st messenger: neurotransmitter

2nd: G protein
3rd: enzyme, phosphorylating something
4th: transcription factors

22
Q

ion channel linked system

A

1st messenger: neurotransmitter

2nd: outflowing calcium
3rd: enzyme
4th: transcription factors

23
Q

G protein and ion channel linked overlap

A

can lead to the same gene expression

24
Q

polymerase

A

opens DNA strand

25
Q

mRNA translation location

A

ribosomes in rough parts of endoplasmatic reticulum

26
Q

well-known early genes

A 
cFos and cJun
make Fos and Jun 
act simultaneously
connect to FosJun protein
through Leucine zipper
are transcription factor for late genes
27
Q

2nd messengers in ion channel linked system

A

can change ion influx

continue or stop electrical impulses

28
Q

kinase and phospatase in earlier stages

A

can act as 1st 2nd or 3rd messengers as well

29
Q

G protein linked system enzymes

A

only kinases

30
Q

ion channel linked system enzymes

A

kinases and phosphatases

Psychopharmacology (6 decks)

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