Pharmacology Lecture 3

Question 1

transcription location

Answer 1

in nucleus

Question 2

translation location

Answer 2

in cytoplasm

Question 3

Ligand gated system

Answer 3

work by attaching something to receptors

Question 4

voltage sensitive system

Answer 4

works by electricity

Question 5

12-transmembrane

Answer 5

plasma membrane transporters

goes from cleft back to neuron

Question 6

main classes of plasma membrane transporters

Answer 6

SLC6: 5HT, DA, NE, GABA, Gly transporters
SLC1: EAAT, a glutamate transporter

Question 7

vesicular transporters

Answer 7

for intracellular transport

Question 8

main classes of vesicular transporters

Answer 8

SLC18
SLC32
SLC17

Question 9

SLC18

Answer 9

VMAT 1 and 2: 5HT, DA and NE

VAChT: Ach transporter

Question 10

SLC32

Answer 10

VIAAT, a GABA transporter

Question 11

SLC17

Answer 11

VGluT1 to 3: glutamate transporter

Question 12

sodium

Answer 12

invalid in transporting neurotransmitters back into neuron

Question 13

fluoxetine

Answer 13

brand name is Prozac

stops that pump that send 5HT back into the neurons

Question 14

dopamine cycle

Answer 14

DAT puts it back into neuron

VMAT2 puts it into vesicle again

Question 15

speed / amphetamine mechanism

Answer 15

replaces DA in transporter and vesicle
more DA in cleft
additional DA released

Question 16

constitutive activity

Answer 16

neutral

not turned off but minimal activity

Question 17

agonist

Answer 17

turns processes in cell on

Question 18

partial agonist

Answer 18

turns some processes on

but not fully

Question 19

antagonist

Answer 19

turns processes of
blocks agonists and partial agonists
neuron goes back to constitutive activity

Question 20

inverse agonist

Answer 20

total inactivation of cell

beyond antagonist

Question 21

silent antagonist

Answer 21

phenomenon that you don’t know whether an antagonist is attached or whether there is just normal constitutive activity

Question 22

allosteric modulation

Answer 22

affects a secondary receptor
when neurotransmitter is already present
opens or closes channels just a bit more or less

Question 23

PAM

Answer 23

positive allosteric modulation

Question 24

NAM

Answer 24

negative allosteric modulation

Question 25

enzyme being active

Answer 25

doing its work

Question 26

enzyme being inactive

Answer 26

not working

Question 27

what do enzymes do

Answer 27

some destroy products

some create products

Question 28

substrate

Answer 28

binds to enzyme

starts release of product sometimes you want to inhibit that

Question 29

irreversible inhibitor

Answer 29

for enzymes
suicide inhibitor
substrate can no longer and never again bind

Question 30

reversible inhibitor

Answer 30

for enzymes

can gain its function back after it gets substrate again