Pharmacology in pregnancy Flashcards
1
Q
What are the main mechanisms for teratogenicity in the first trimester?
A
- Folate antagonism
- Neural crest disruption
- Endocrine disruption
- Oxidative stress
- Vascular disruption
2
Q
What is fetotoxicity?
A
Toxic effect of drug on the foetus later in pregnancy
3
Q
What fetotoxic effects does alcohol have?
A
Foetal alcohol syndrome
4
Q
What fetotoxic efffect does benzodiazepines have?
A
Floppy infant syndrome
5
Q
What are the tertogenic effects of carbemazepine?
A
Spina bifida/neural tube malformations
6
Q
What problem can occur when using tetracyclines during lactation?
A
Permanent tooth staining of child
7
Q
What problems can occur when using barbituates when breastfeeding?
A
- Lethargy
- Sedation
- Poor suck reflex
