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Primary exam - extra > Pharmacology extra > Flashcards

Pharmacology extra Flashcards

1
Q

PkA of most locals

where is uptake increased

A

8-9 as infected tissue low PH

base

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2
Q

drug of choice for vivax and ovale

what doesnt work against liver/tissue malaria

A

primaquine

chloroquine

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3
Q

what is loading dose propertional to

A

accumulation factor

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4
Q

average glycogen store

A

300-400mg

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5
Q

where does ceftriaxone achieve high concentraions

A

urine and bile

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6
Q

what can paracetamol not undergo

A

deamination

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7
Q

what do all benzos undergo?

A

hepatic metabolism

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8
Q

toxic effect organic nitrates

A

methoglob

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9
Q

what can cause dig toxicity

A

hypercalcaemia

hypomag

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10
Q

what is used to treat CMV

A

ganiclovir

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11
Q

inhaled anaesthetic in IHD

A

isoflurane

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12
Q

most cardiotoxic antipsychotix

A

thiorizadine

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13
Q

when do penicillins cros BBB

A

when meningis enflamed

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14
Q

which penicillin doesnt need adjustment in renal failure

A

dicloxicillin

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15
Q

which common receptor is ligand gated

A

nicotinic

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16
Q

heavy metal antidote

A

EDTA

BAL

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17
Q

what is paralysed first

last

A

jaw and eye

diaphragm

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18
Q

is atropine reversible?

how much excretd in urine

A

yes

50

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19
Q

how does organophosphate poisoining work

Treatment

A

cholinergic

pralidoxime

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20
Q

half life of amphotericin b

A

2 weeks

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21
Q

how does vigabactrin work

A

GABA

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22
Q

what metabolises diazepam

A

desmethyl diazepam

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23
Q

zero order kinetics

A

Ps

WHEATS

phenytoid

warfarin

heparin

ethanol

asprin

theophyline

salicylates

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24
Q

nucleotide HIV meds

A

have T in them

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25
Q

lithium bioavailibility

A

100%

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26
Q

how does NO reduce exertional CP

A

reduce o2 consumption

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27
Q

does dopamine cross BBB

A

no

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28
Q

super inducers and codeine =

A

morphine

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29
Q

how does gent get into cell

A

passive then active diffusion

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30
Q

what inactivates dopamine

A

sodium bicarb

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31
Q

ihaled anaesthetics reduced map is proportional to?

A

alveolar concentraion

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32
Q

do you change isonizid dose in renal failure

A

no

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33
Q

shortest nsaid half life

longest

A

diclofenac

piroxicam - over 2 days

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34
Q

intracellular PH

A

7

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35
Q

what increases erythromycin half life

A

anuria

36
Q

what synthesis ACH

A

choline acetyletransferase

37
Q

treatment for MG

A

neostigmine (cholinomimetic)

38
Q

lidocaine and dig

A

used in VT

39
Q

what increases risk of TCA toxicity

A

metabolic acidosis

40
Q

how do LA become charged?

A

gaining proton

41
Q

normal ethanol vofd

A

49

42
Q

paraquat mode of toxicity

dose

time scale

A

single election reduction

50-500mg/kg

can take weeks

43
Q

first pass drugs

A

filth

isoprelanine

lidocaine

testosterone

hydrocortisone

44
Q

rectal 1st pass percentage

A

50

45
Q

where does serotonin not vasoconstrict

A

heart - it dilates

46
Q

in first order kinetics does half life increase with dose?

A

no

47
Q

beta blockers with agonist activity

A

labetalol

cartelol

48
Q

riskietst block due to levels

A

intercostal

49
Q

CO in atmosphere

hyperbaric indication

A

0.1ppm

symptoms

50
Q

how to azoles work

A

inhibit fungal p450

51
Q

propofil v thiopentone

A

less post op vomiting

52
Q

what exhibits bioaccumulation

A

mercury

53
Q

what is synergistic with penicillin in meningitis

A

tetracyclines

54
Q

what acts on intracellular receptors

A

steroids

55
Q

why does trimethoprim affect humans

A

endogenous folate

56
Q

most CV stable anesthetic

A

etomidate

57
Q

lead neuropathy site

A

upper limb extensors

58
Q

suc and K

A

increase

OK in eye ops

59
Q

how do sulphanureas work

A

stop K eflux and cause depolarisation

60
Q

thrombocytopenic rash

A

co-trimoxazole

61
Q

when ceph for bacteriodis fragilis

A

cefoxitin

62
Q

flumazenil + mixed OD

A

seizure

63
Q

how is dig excreted

A

unchanged in urine

64
Q

inhaled anaesthetic and tachy

A

isoflurane and desflurane

65
Q

how does colchicine work

A

inhibits polymorphs

66
Q

pancuronium excreteion

atacarium?

A

kidney

hoffman

67
Q

side effect of mannitol

A

pulmonary oedema

68
Q

ph=pka

A

half ionized half not

69
Q

how does cipro work

A

naladixic acid analogue

topsoimerase 2 and 4

70
Q

how does gent ototoxicity manifest

A

vestibular dysfunction

71
Q

what goes from phase 1 to 2 and icnreaing concentrations

A

succ

72
Q

what is an irreversible antagonist dependent on

A

turnover of receptors

73
Q

what can propranolol do to fat

A

increase triglycerides

74
Q

what can block tramadol

A

ondansetron

75
Q

what does fluoxetine inhibit

A

cyp2d6

76
Q

what does metoclopramide to do LOS

A

increase pressure

77
Q

what doesnt dig do

A

affect atrium

78
Q

when can you use diphendramine

A

motion sickness

79
Q

side effect of isoprenaline in asthma

A

arrhtymias

80
Q

worst nsaid for gi

A

indomethacin

81
Q

what can cause glaucoma

A

homatropine

82
Q

how is potassium excreted

A

renally

83
Q

when can you use haloperidol

A

tourettes

84
Q

common side effect of propoful

A

bradycardia

85
Q

what DI does lithium cause

A

nephrogenic

86
Q

what does percent equal

A

GRAMS IN 100ml

Primary exam - extra (5 decks)

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