Pharmacology extra Flashcards by Ryan Govier

PkA of most locals

where is uptake increased

8-9 as infected tissue low PH

base

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drug of choice for vivax and ovale

what doesnt work against liver/tissue malaria

primaquine

chloroquine

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what is loading dose propertional to

accumulation factor

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average glycogen store

300-400mg

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where does ceftriaxone achieve high concentraions

urine and bile

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what can paracetamol not undergo

deamination

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what do all benzos undergo?

hepatic metabolism

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toxic effect organic nitrates

methoglob

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what can cause dig toxicity

hypercalcaemia

hypomag

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what is used to treat CMV

ganiclovir

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inhaled anaesthetic in IHD

isoflurane

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most cardiotoxic antipsychotix

thiorizadine

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when do penicillins cros BBB

when meningis enflamed

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which penicillin doesnt need adjustment in renal failure

dicloxicillin

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which common receptor is ligand gated

nicotinic

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heavy metal antidote

EDTA

BAL

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what is paralysed first

last

jaw and eye

diaphragm

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is atropine reversible?

how much excretd in urine

yes

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how does organophosphate poisoining work

Treatment

cholinergic

pralidoxime

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half life of amphotericin b

2 weeks

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how does vigabactrin work

GABA

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what metabolises diazepam

desmethyl diazepam

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zero order kinetics

WHEATS

phenytoid

warfarin

heparin

ethanol

asprin

theophyline

salicylates

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nucleotide HIV meds

have T in them

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lithium bioavailibility

100%

how does NO reduce exertional CP

reduce o2 consumption

does dopamine cross BBB

super inducers and codeine =

morphine

how does gent get into cell

passive then active diffusion

what inactivates dopamine

sodium bicarb

ihaled anaesthetics reduced map is proportional to?

alveolar concentraion

do you change isonizid dose in renal failure

shortest nsaid half life longest

diclofenac piroxicam - over 2 days

intracellular PH

what increases erythromycin half life

anuria

what synthesis ACH

choline acetyletransferase

treatment for MG

neostigmine (cholinomimetic)

lidocaine and dig

used in VT

what increases risk of TCA toxicity

metabolic acidosis

how do LA become charged?

gaining proton

normal ethanol vofd

paraquat mode of toxicity dose time scale

single election reduction 50-500mg/kg can take weeks

first pass drugs

filth isoprelanine lidocaine testosterone hydrocortisone

rectal 1st pass percentage

where does serotonin not vasoconstrict

heart - it dilates

in first order kinetics does half life increase with dose?

beta blockers with agonist activity

labetalol cartelol

riskietst block due to levels

intercostal

CO in atmosphere hyperbaric indication

0.1ppm symptoms

how to azoles work

inhibit fungal p450

propofil v thiopentone

less post op vomiting

what exhibits bioaccumulation

mercury

what is synergistic with penicillin in meningitis

tetracyclines

what acts on intracellular receptors

steroids

why does trimethoprim affect humans

endogenous folate

most CV stable anesthetic

etomidate

lead neuropathy site

upper limb extensors

suc and K

increase OK in eye ops

how do sulphanureas work

stop K eflux and cause depolarisation

thrombocytopenic rash

co-trimoxazole

when ceph for bacteriodis fragilis

cefoxitin

flumazenil + mixed OD

seizure

how is dig excreted

unchanged in urine

inhaled anaesthetic and tachy

isoflurane and desflurane

how does colchicine work

inhibits polymorphs

pancuronium excreteion atacarium?

kidney hoffman

side effect of mannitol

pulmonary oedema

ph=pka

half ionized half not

how does cipro work

naladixic acid analogue topsoimerase 2 and 4

how does gent ototoxicity manifest

vestibular dysfunction

what goes from phase 1 to 2 and icnreaing concentrations

succ

what is an irreversible antagonist dependent on

turnover of receptors

what can propranolol do to fat

increase triglycerides

what can block tramadol

ondansetron

what does fluoxetine inhibit

cyp2d6

what does metoclopramide to do LOS

increase pressure

what doesnt dig do

affect atrium

when can you use diphendramine

motion sickness

side effect of isoprenaline in asthma

arrhtymias

worst nsaid for gi

indomethacin

what can cause glaucoma

homatropine

how is potassium excreted

renally

when can you use haloperidol

tourettes

common side effect of propoful

bradycardia

what DI does lithium cause

nephrogenic

what does percent equal

GRAMS IN 100ml