Pharmacology - Drugs (histamine, Glutamate, cholinergic)

Question 1

Give 2 examples of histamine drugs that work on the H1 and H3 sites?

Answer 1

HYDROXYMINE

MECLOZINE

Question 2

Give an example of a histamine drug that works on the H2 site?

Answer 2

FAMOTIDINE

Question 3

Give 2 examples of direct acting glutamate antagonists drugs?

Answer 3

MEMANTINE

KETAMINE

Question 4

Give an example of an indirect - acting glutamate antagonist

Answer 4

LAMOTRIGINE

Question 5

Give an example of a direct acting cholingeric drug that binds at nicotinic receptors?

Answer 5

NICOTINE

• counters cravings for cigarettes.

Question 6

Give an example of a direct acting cholinergic drug that binds to muscarine receptors?

Answer 6

BETHANECHOL

• increases bladder emptying.

Question 7

Give 3 examples of a indirect acting cholinergic drugs.

Answer 7

DISTIGMINE

• stimulated GI tract motility and increase bladder output.. Used post - op to counter muscle relaxant effects.

DONEPEZIL

• Promotes brain/memory function. Used as a therapy for senile dementia’s such as Alzhemiers Disease.

PYRIDOSTIGMINE

• increases muscle contraction for muscle wasting diseases such as Myasthenia Gravis.

Question 8

Give 2 examples of drugs that are direct acting cholinergic blocking with peripheral therapeutic actions.

Answer 8

ATROPINE

• ‘antidote’ to mushroom poisoning. GI tract muscles being relaxed.

TOPICAL BELLADONNA

• should relax muscles. Used to relieve symptoms of rheumatism arthritis and stress.

Question 9

Give an example of a drug that is a direct acting cholinergic blocking drug with central therapeutic actions.

Answer 9

BENZTROPINE

• relaxes muscles so can reduce muscle tremors in Parkinson’s.

Question 10

Give an example of an indirect acting cholinergic blocking drug.

Answer 10

Botulinum Toxins (BOTOX)

• Used in cosmetic surgery to paralyse the muscle.