Pharmacology core drugs

Question 1

salbutamol binds/activates

Answer 1

beta2 adrenoceptors

Question 2

salbutamol treats…

Answer 2

acute symptoms of asthma

Question 3

salbutamol causes

Answer 3

bronchodilation- desired therapeutic effect for asthma

Question 4

propranolol is a

Answer 4

beta blocker

Question 5

propranolol binds to

Answer 5

beta1 and beta 2 adrenoceptors

Question 6

increasing conc of propranolol does what to isoprenaline

Answer 6

causes its conc-response curve to shift to the right

Question 7

amitriptyline is a what

Answer 7

anti-depressant drug

Question 8

amitriptyline is an agonist/antagonist?

Answer 8

antagonist at NET and SERT, H2 histamine receptor, Ach M1, M2, M3, M4, M5 receptors

Question 9

side effects of amitriptyline

Answer 9

sedation- caused by blockage of H2 histamine receptors
dry mouth and constipation- caused by blockage of muscarinic Ach receptors

Question 10

propranolol treats

Answer 10

heart and circulatory conditions-
tremors
angina
hypertension
heart rhythm disorders…….

Question 11

antenolol treats

Answer 11

high blood pressure
heart associated chest pain

Question 12

when should you not use propranolol

Answer 12

when you have asthma, allergic to it, history of slow heart beats that have caused fainting, severe heart failure, severe heart condition

Question 13

beta blockers mechanism of action

Answer 13

binds to beta 1 only/beta 1 and 2- lowers heart rate and blood pressure

Question 14

beta blockers administration

Answer 14

orally

Question 15

aspirin blocks

Answer 15

COX (cyclooxygenase)

Question 16

aspirin inhibits

Answer 16

TXA2 synthesis
production of PG12

Question 17

avoid aspirin if

Answer 17

bleeding disorders or peptic ulcers

Question 18

adverse effects of aspirin

Answer 18

GI bleeding and ulceration

Question 19

aspirin administration

Answer 19

orally

Question 20

aspirin treats

Answer 20

ischaemic strokes
acute coronary syndrome
arterial thrombosis