Pharmacology Black Book - Pharmacokinetics & Pharmacodynamics

Question 1

1) The volume of distribution

a) is calculated by dividing the amount of drug by it’s clearance
b) if high suggests homogeneous distribution throughout tissues
c) if low suggests homogeneous distribution throughout tissues
d) of aspirin is greater than pethidine
e) of midazolam is greater than warfarin

Answer 1

E

Question 2

2) The volume of distribution

a) is proportional to half life
b) is inversely proportional to clearance
c) is used to work out maintenance dose
d) is measured in mg/L
e) is high in warfarin

Answer 2

A

Question 3

3) Calculate the half life of digoxin in a patient with a renal clearance of 8.4L/min and Vd of digoxin of 5 L/Kg in a 70 Kg man

a) 8 hours
b) 14 hours
c) 29 hours
d) 36 hours
e) 44 hours

Answer 3

? I’m thinking maybe it’s C but the question should have said that the clearance was 8.4L/hr ?

Question 4

5) The volume of distribution

a) is less than 70 L for fluoxeteine
b) is calculated by dividing rate of elimination by concentration
c) is inversely proportional to half life
d) is about 5L/kg for pethidine
e) is effected by the route of drug administration

Answer 4

D

Question 5

6) The bioavaliability of a drug

a) must be 100% if given by inhalation
b) is typically 75 % if given intravenously
c) is high if the drug is hydrophillic
d) is equal to 1 - the extraction ratio
e) is 70% for orally administered digoxin

Answer 5

E

Question 6

7) Type 1 biotransformation reactions include

a) methylation
b) acetylation
c) oxidation
d) glucuronidation
e) sulphonation

Answer 6

C