Pathology Black Book - from Robbin's 7th ed Chapter 2 - Inflammation Flashcards
In acute inflammation
a. A hallmark is reduced vascular permeability
b. Vasodilation is a late manifestation
c. Extravasation involves movement of leukocytes from interstitial tissue to the vessel lumen
d. Chemotaxis is migration of leukocytes along a chemical gradient
e. Selectins have a minor role
D
In acute inflammation which event occurs first
a. Arteriolar dilatation
b. Arteriolar constriction
c. Oedema
d. Leucocyte migration
e. Blood flow stasis
Apparently it’s B (iMeducate). There is initially a brief period of vasoconstriction (a few seconds), followed by vasodilation. (However, if you read Robbins and Cotran 9th edition chapter 3, the section on “Acute Inflammation”, it would have you believe that vasodilation is the first thing to happen. It doesn’t seem to mention anything about vasoconstriction.)
The first vascular response to injury is
a. Slowing of the circulation
b. Venular dilation
c. Recruitment of vascular beds
d. Capillary engorgement
e. Arteriolar vasoconstriction
E
Leukocytes move into tissues from the vasculature (extravasation)
a. by the action of actin and myosin
b. predominantly as monocytes on the first day post injury
c. in response to C3b
d. in response to the Fc fragment of IgG
e. largely in the arterioles
It could be A (but this is only relevant for the leukocyte’s migration after it has left the blood vessel)
It also could be B, if the question is referring to the period 24-48 hours after the injury.
Regarding chemical mediators of inflammation
a. Histamine is derived from plasma
b. C3b is within macrophages
c. The kinin system is activated in platelets
d. Nitric oxide is preformed in leukocytes
e. Serotonin is preformed in mast cells
E
Chronic inflammation is
a) always preceded by acute inflammation
b) characterised by hyperemia, oedema and leukocyte infiltration
c) most frequently results in resolution
d) the factors underlying monocyte infiltration are the same as for acute inflammation
D
