Pharmacology - Antibio, Antifungic, Antiparasitic Flashcards
Nocardicin
Antibio : Betalactam (mono)
Aztreonam
Antibio : Betalactam (mono)
Carumomam
Antibio : Betalactam (mono)
Tigemomam
Antibio : Betalactam (mono)
Action of betalactam
Bactericidal - cell wall synthesis
Number of penicillin generation
6
Penicillin G
Penicillin V
Antibio : Betalactam (di)
Oxacillin
Antibio : Betalactam (di)
Meticillin
Antibio : Betalactam (di)
- nephrotoxic
Nafcillin
Antibio : Betalactam (di)
- only intrammammary
Ampicillin
Antibio : Betalactam (di)
Amoxicillin
Antibio : Betalactam (di)
Pivampicillin
Antibio : Betalactam (di)
Talampicillin
Antibio : Betalactam (di)
Mecillinam
Antibio : Betalactam (di)
Carbenicillin
Antibio : Betalactam (di)
Azlocillin
Antibio : Betalactam (di)
Mezlocillin
Antibio : Betalactam (di)
Piperacillin
Antibio : Betalactam (di)
Clavulanic acid
Antibio : Betalactam (di)
Sulbactam
Antibio : Betalactam (di)
Ritipenem
Antibio : Betalactam (di)
Imipenem
Antibio : Betalactam (di)
Meropenem
Antibio : Betalactam (di)
Number of generation of cephalosporin
4
Cefazolin
Antibio : Betalactam (di)
Cephalexin
Antibio : Betalactam (di)
Cefotiam
Antibio : Betalactam (di)
Cefoperazone
Antibio : Betalactam (di)
Cefotaxim
Antibio : Betalactam (di)
Moxolactam
Antibio : Betalactam (di)
Cefquinome
Antibio : Betalactam (di)
Bacteria targeted by each generation of cephalosporins
From 1st gen : mainly gram+
To 5th gen : mainly gram-
Loracarbef
Antibio : Betalactam (di)
Action of aminoglycoside
Bactericidal
Bacteriostatic at low concentration
30S subunit
Streptomycin
Antibio : Aminoglycosides
Dihydrostreptomycin
Antibio : Aminoglycosides
- only oral admin
Neomycin (A, B, C)
Antibio : Aminoglycosides
Paromomycin (I, II)
Antibio : Aminoglycosides
Antiparasitic - Protozoa (Amoebas and flagellates) (Leishmania, Cryptosporidia)
Kanamycins (A, B, C)
Antibio : Aminoglycosides
Gentamycin
Antibio : Aminoglycosides
Apramycin
Antibio : Aminoglycosides
- TOXIC FOR CATS
Enroflaxin
Antibio : Quinolones, Fluoroquinolones
Action of quinolones and fluoroquinolone
Bactericidal
DNA gyrase
Avoid young animals (cartilage damages)
Avoid species for milk prod and laying hens
Number of generation of quinolones
3 (3rd = fluoroquinolone)
Norfloxacin
Antibio : Quinolones, Fluoroquinolones
Ciprofloxacin
Antibio : Quinolones, Fluoroquinolones
Difloxacin
Antibio : Quinolones, Fluoroquinolones
Marbofloxacin
Antibio : Quinolones, Fluoroquinolones
Oxolinic acid
Antibio : Quinolones, Fluoroquinolones
Enoxacin
Antibio : Quinolones, Fluoroquinolones
Nalidixic acid
Antibio : Quinolones, Fluoroquinolones
Pipemidic acid
Antibio : Quinolones, Fluoroquinolones
Piromidic acid
Antibio : Quinolones, Fluoroquinolones
Ofloxacin
Antibio : Quinolones, Fluoroquinolones
Flumequine
Antibio : Quinolones, Fluoroquinolones
Action of macrolides
Bacteriostatic
Bactericidal at high C°
50S
Narrow spectrum
Erythromycin
Antibio : Macrolides
Spiramycin
Antibio : Macrolides
Midecamycin
Antibio : Macrolides
Azithromycin
Antibio : Macrolides
Lankacidin
Antibio : Macrolides
Dirithromycin
Antibio : Macrolides
Telithromycin
Antibio : Macrolides
- resp tract infection
Tilmycosin
Antibio : Macrolides
- bovine resp disease
Action of lincosamides
C° dependent : bactericidal/bacteriostatic
50S
HORSE AND RODENT ARE SENSITIVE
Clindamycin
Antibio : Lincosamides
- Toxoplasma, Neospora, Hemosporozoa
Lincomycin
Antibio : Lincosamides
- anaerobic
Action of streptogramins
Bactericidal if synergism/bacteriostatic
50S
Anaerobes, gram+, toxoplasmosis
Viginiamycin
Antibio : Streptogramins
Pristinamycin
Antibio : Streptogramins
Quinupristin
Antibio : Streptogramins
Dalfopristin
Antibio : Streptogramins
Action of ansamycin
RNA polymerase
Gram+
Red/orange coloration of fluid
Rifamycin
Antibio : Ansamycin
Rifamid
Antibio : Ansamycin
Rifampicin
Antibio : Ansamycin
Action of polypeptides antibio
Bactericidal (cell membrane for polymyxin, cell wall for bacitracin)
Gram -
Parenteral admin = neurotoxic effect
Polymyxin B, E
Antibio : Polypeptide antibio (polymyxin)
Vancomycin
Antibio : Polypeptide antibio (bacitracin)
- gram+, anaerobes
- ototoxic, nephrotoxic
Avoparcin
Antibio : Polypeptide antibio (bacitracin)
Teicoplanin
Antibio : Polypeptide antibio (bacitracin)
Daptomycin
Antibio : Polypeptide antibio (bacitracin)
Action of tetracyclines
- Bacteriostatic (30S)
- High concentration in urine -> bactericidal
- broad spectrum
- chelate Ca ion : irreversible in bone, dentin, enamel
Antiparasitic - Protozoa (Amoebas and flagellates, Theileria, Ciliates)
Chlortetracycline
Antibio : Tetracyclines
- Babesia
Oxytretracycline
Antibio : Tetracyclines
- resp diseases
- intolerance in DOGS and CALVES : hypersensitivity reaction after i.m.
Tetracycline
Antibio : Tetracyclines
- anaphylactic shock in DOGS after i.v.
Demethylchlortetracycline
Antibio : Tetracyclines
Doxycyclin
Antibio : Tetracyclines
- excreted by feces, can be used even if renal pb
- highly TOXIC in HORSES
- can cause vomiting in CATS and DOGS
- Babesia
Metacyclin
Antibio : Tetracyclines
Minocyclin
Antibio : Tetracyclines
Action of phenicols
- broad spectrum
- bacteriostatic (-cidal at high C°) (50S)
- prohibited for animals for human consumption
Thiamphenicol
Antibio : Phenicols
- not in lactating animals
Chloramphenicol
Antibio : Phenicols
- side effect : anemia
Florfenicol
Antibio : Phenicols
- bacteriostatic : enteric pathogens
- bactericidal : bovine resp tract pathogens
- not in lactating animals and laying hens
Action of diaminopyrimidines
- bacteriostatic (interfere with folate formation)
Action of sulfonamides
- bacteriostatic (- cidal at high C° in urine) (anti-metabolites)
Trimethoprim
Antibio : Diaminopyrimidines
Antiparasitic - Protozoa (Hemosporozoa)
Aditoprim
Antibio : Diaminopyrimidines
Ormethoprim
Antibio : Diaminopyrimidines
Metoprim
Antibio : Diaminopyrimidines
Baquiloprim
Antibio : Diaminopyrimidines
Pyrimethamine
Antibio : Diaminopyrimidines
Antiparasitic - Protozoa (toxoplasmosis)
Action of sulfonamide
Antibio
Antiparasitic - Protozoa (toxoplasmosis)
Sulfacetamide
Antibio : Sulfonamides
Sulfadiazine
Antibio : Sulfonamides
Antiparasitic - Protozoa (Coccidia, Hemosporozoa)
Sulfadimidine
Antibio : Sulfonamides
Sulfadoxine
Antibio : Sulfonamides
Antiparasitic - Protozoa (Coccidia)
Sulfanitran
Antibio : Sulfonamides
Antiparasitic - Protozoa (Coccidia)
Sulfadimethoxine
Antibio : Sulfonamides
Antiparasitic - Protozoa (Coccidia)
Sulfoquinoxaline
Antibio : Sulfonamides
- local GI action
Antiparasitic - Protozoa (Coccidia)
Sulfaguanidine
Antibio : Sulfonamides
- local GI action
Antiparasitic - Protozoa (Coccidia)
Action of oxazolidinones
- 50S
Eprezolide
Antibio : Oxazolidinones
Linezolide
Antibio : Oxazolidinones
Action of pleuromutilins
- bacteriostatic (-cidal at high C°) (block proteoshynthesis)
- incompatible with IONOPHORES : serious intoxication
Tiamulin
Antibio : Pleuromutilins
- for pigs and birds
- DO NOT use product with IONOPHORES 7 days before and after treatment
Valnemulin
Antibio : Pleuromutilins