Pharmacology: Antacids

Question 1

How long are Antacids use?

Answer 1

short term temporary releif

Question 2

low systemic antacids

Answer 2

Aluminum, calcium, and magnesium based agents

-less systemically absorbed

Question 3

High systemic antacid

Answer 3

Sodium based

-sodium bicarbonate

Question 4

Do antacids reduce acid secretion?

Answer 4

no

-they just neutralize acid

Question 5

Which antacids work faster?

Answer 5

Calcium and magnesium

-they last longer too

Question 6

What was the miscellaneous product?

Answer 6

Simethicone

• aids in the expulsion of gas
• pro fart
• it’s a surfactant… makes a bunch of bubbles into one honkin bubble

Question 7

which one lowers our phosphate?

Answer 7

aluminum

Question 8

Calcium adverse effect?

Answer 8

Constipation

-starts with C

Question 9

how many drug interactions are there?

Answer 9

TONS!

Question 10

when do you take an antacid?

Answer 10

1-2 hours before other medications or 2-4 hrs after other meds

Question 11

ending of H2 receptor antagonists?

Answer 11

“tidine”

Question 12

PPI endings

Answer 12

“prazole”

Question 13

Surface Acting agents

Answer 13

Sulcrflate

Question 14

What does the H2 receptor do?

Answer 14

increase Acid production via Camp mediated pathway

Question 15

how long does ulcer healing take with H2 antagonists?

Answer 15

4-8 weeks… takes a while for the tissue to heal back

Question 16

which weird adverse effect does cimetidine give us?

Answer 16

gynecomastia in men…. super rare

-galactorrhea in women

Question 17

Cimetidine is an ihibitor of several what kind of isoenzymes?

Answer 17

CYP450 enzymes

Question 18

Which H2 blocker do we give to preggo ppl?

Answer 18

Ranitidine

Question 19

PPI’s… can they reduce the amount of acid produced?

Answer 19

yes!

Question 20

Which people do we need to give A LOT OF PPI’s to?

Answer 20

ZE syndrome ppl

-gastrin secreting tumor

Question 21

Adverse effect of PPI’s

Answer 21

CDAD

-C dif associated diarrhea

Question 22

Which PPI has a lot of CYP 450 inhibition?

Answer 22

Omeprazole!

Question 23

Sucralfate

Answer 23

a sulfated polysaccharide

-creates a bandaid thing on the ulcer

Question 24

What is the one PG analogue we talked about?

Answer 24

Misoprostol

-provides cytoprotection… lots of mucus protection

Question 25

What is Misoprostol indicated in?

Answer 25

prevention of NSAID-induced gastric ulcerations

-makes sense because those will decrease our COX enzyms

Question 26

What happens when you take bismuth?

Answer 26

melena

• black/dark stools
• normally shaped
• if abnormally shaped, it’s a GI bleed

Question 27

What do we worry about with bismuth

Answer 27

bleeding a lot

-it’s a subsalicylate

Question 28

Treating H. Pylori

Answer 28

10-14 days of a triple therapy= a PPI and 2 antibiotics

Question 29

Triple therapy

Answer 29

• Clarithromycin
• A PPI
• and Amoxicillin or metronidazole

Question 30

Quadruple therapy

Answer 30

• PPI
• Metronidazole or Clarithromycin
• Amoxicillin or tetracycline
• bismuth subsalicylate

Question 31

What is Prevpac?

Answer 31

• amoxicillin
• clarithromycin
• lansoprazole

Question 32

Omeclamox

Answer 32

Amoxicillin
Clarithromycin
Omeprazole

Question 33

Helidac

Answer 33

Bismuth
Metronidazole
Tretracycline
PLUS THE ADDITION OF A PPI OR H2 ANTAGONIST

Question 34

Pylera

Answer 34

BMT plus extra addition of a PPI (omeprazole)

Question 35

What do sub if they have a PCN allergy?

Answer 35

metronidazole

Question 36

Metronidazole resistance?

Answer 36

Tetracycline

-consider quadruple therapy

Question 37

Clarithromycin resistance?

Answer 37

Amoxicillin or Tetracycline

-consider quadruple therapy

Question 38

Pregnant lady with H pylori?

Answer 38

Moderate: ranitidine
Severe: lansoprazole

Question 39

NSAID at risk

Answer 39

stop it!

-but if you can’t, give them misoprostol or COX2 NSAID