Pharmacology: Antacids Flashcards
How long are Antacids use?
short term temporary releif
low systemic antacids
Aluminum, calcium, and magnesium based agents
-less systemically absorbed
High systemic antacid
Sodium based
-sodium bicarbonate
Do antacids reduce acid secretion?
no
-they just neutralize acid
Which antacids work faster?
Calcium and magnesium
-they last longer too
What was the miscellaneous product?
Simethicone
- aids in the expulsion of gas
- pro fart
- it’s a surfactant… makes a bunch of bubbles into one honkin bubble
which one lowers our phosphate?
aluminum
Calcium adverse effect?
Constipation
-starts with C
how many drug interactions are there?
TONS!
when do you take an antacid?
1-2 hours before other medications or 2-4 hrs after other meds
ending of H2 receptor antagonists?
“tidine”
PPI endings
“prazole”
Surface Acting agents
Sulcrflate
What does the H2 receptor do?
increase Acid production via Camp mediated pathway
how long does ulcer healing take with H2 antagonists?
4-8 weeks… takes a while for the tissue to heal back
which weird adverse effect does cimetidine give us?
gynecomastia in men…. super rare
-galactorrhea in women
Cimetidine is an ihibitor of several what kind of isoenzymes?
CYP450 enzymes
Which H2 blocker do we give to preggo ppl?
Ranitidine
PPI’s… can they reduce the amount of acid produced?
yes!
Which people do we need to give A LOT OF PPI’s to?
ZE syndrome ppl
-gastrin secreting tumor
Adverse effect of PPI’s
CDAD
-C dif associated diarrhea
Which PPI has a lot of CYP 450 inhibition?
Omeprazole!
Sucralfate
a sulfated polysaccharide
-creates a bandaid thing on the ulcer
What is the one PG analogue we talked about?
Misoprostol
-provides cytoprotection… lots of mucus protection
