Pharmacology Flashcards
Mesocortical pathway
Negative symptoms
Mesolimbic pathway
Positive symptoms
Tuberoinfundibular pathway
Prolactin increase (due to loss of inhibition by dopamine)
Nigrostriatal
EPS
Most loose binding @ D2?
Clozapine
Seroquel
D2 blockade needed for efficacy?
68%
D2 blockade needed for hyperprolactinemia?
72%
D2 blockade needed for EPS?
80%
Abilify mechanism?
Partial agonist 5HT1A
Antagonist 5HT2A
Receptors associated with weight gain?
5HT2C
Histamine
Alpha 1 antagonism
Tachycardia
Increased salvation
Urinary incontinence
Priapism
Alpha 2 antagonism
Sexual dysfunction
Which antipsychotic does not cause QT prolongation?
LATUDA
Anticholinergic effect of antipsychotics?
Dopamine INHIBITS acetylcholine.
LOW potency APs are more ANTICHOLINERGIC (Clozapine, Seroquel)
The MORE anticholinergic you are, the LESS your risk for NMS
Serious side effect of Flumazenil (benzo intox treatment)?
SEIZURE
Lithium tremor
Fine, rapid
Increases with fine movements and when maintaining posture
Treat with BETA-BLOCKER
Akathisia most common with which AP?
ABILIFY
Which antidepressants don’t cause SIADH?
Mirtazapine
Wellbutrin
No anticholinergics for?
AKATHISIA
TD
No beta-blockers for?
DYSTONIA
Which medication can you not take while on Clozapine?
CARBAMAZEPINE
combined myeloproliferative disease
Agranulocytosis
1%
1st year of treatment
NOT dose dependent