CL Flashcards
Shared care
Degree of collaboration does not predict outcome.
INTENSITY OF FOLLOW-UP does!
Which antidepressant for HIV depression?
CELEXA
CIPRALEX
Frequent response to sub therapeutic doses
Major NCD due to HIV
SUBCORTICAL
Affects 10% of HIV patients
CD4 < 200 = risk factor
SEIZURES ARE NOT AN EARLY COMPLICATION
Neurosyphilis
First manifestation is MENINGITIS
Tremors
Dysarthria
HYPOreflexia
ARGILL ROBERTSON PUPILS (accommodate to object but don’t react to light)
Affects FRONTAL LOBE, progresses to dementia
SLE
Most frequent presentation is DEPRESSION
Anti-nuclear antibodies Malar rash Pericardial/pleural effusif Splenomegaly/hepatomegaly Lymphadenopathy
Psychiatric illness associated with EXOGENOUS steroids?
MANIA
ANXIETY
Psychiatric illness associated with ENDOGENOUS steroids?
(Cushing)
DEPRESSION
Psychological factors affecting other medical conditions
One of the following ways:
- Factors have influenced the course of the medical condition as shown by close temporal association between the psychological factors and the development or exacerbation of the medical condition.
- The factors interfere with the treatment of the medical condition (ex: poor adherence).
- The factors constitute additional well-established health risks for the individual (ex: using insulin to lose weight in diabetic patient).
- The factors influence the underlying pathophysiology precipitating or exacerbating symptoms or necessitating medical attention (ex: anxiety exacerbating asthma).
Example of severe: ignoring heart attack symptoms
What psychiatric manifestation most commonly associated with IBD?
ALEXITHYMIA
HYPOthyroidism
Most common manifestation = COGNITIVE DEFICITS
Also = depression, anxiety, rapid cycling
MYXEDEMA MADNESS (psychosis)
Can be caused by:
Lithium
Interferon
Amiodarone
HYPERthyroidism
Most common manifestation = DEPRESSION
Also = anxiety, cognitive, mania, psychosis
HYPERparathyroidism
HYPERcalcemia (correlates with symptom severity)
Most frequent presentation = DEPRESSION, anergia
Caused by Lithium
Symptoms: abdominal pain constipation renal stone fatigue confusion PROXIMAL muscle weakness
(Stones, bones, groans and psychic overtones)
Which medical condition has highest risk of MDE?
CANCER
Physical manifestation of increased ICP?
Cushing’s triad
BRADYCARDIA
High systolic BP
Irregular respirations
Psychological reactions to cardiac events?
1-2 days denial
4-5 days hostile-dependent
Vitamin B12 deficiency
Most frequent presentation = ANXIETY, COGNITIVE
Hyporeflexia Glossitis Spasticity \+ Babinski BLINDNESS FOR BLUE AND YELLOW Decreased smell & taste Hyperpigmented nails
(LEMON SKIN, SHINY TONGUE, SLUGGISH)
May be caused by
PPI
methotrexate
metformin
B12 needed to regenerate folate in body
Which medication has no link with MDD?
B-BLOCKER
Sydenham chorea
Also group A strep
RHEUMATIC FEVER
Which stroke causes OCD?
BASAL GANGLIA
Which AD post-MI?
SERTRALINE
Treatment depression post-TBI?
Sertraline
FLAME trial with Prozac
Most common psychiatric illness post-TBI
Depression
No association with severity
Risk factors:
Left front and left basal ganglia lesions
Dysphoria at 1 week
Past depression
(according to K&S)
Wilson’s disease
Autosomal recessive
Carrier rate = 1%
Increased copper in CSF AND URINE
Decreased ceruloplasmin in serum
Presents as LIVER DISEASE IN YOUNG (10-40yo)
Other manifestations = psychosis, personality changes, movement disorder
Dystonic vs. pseudosclerotic forms
KAISER FLEISCHER RINGS
Tumor in which brain regions cause most psychiatric symptoms?
FRONTAL or LIMBIC> parietal or temporal
Epilepsy
Most clearly associated with PSYCHOSIS (7-12%)
and personality change (according to K&S)
30-50% have psychiatric difficulties
Suicide risk 5x higher and up to 25x higher if temporal epilepsy!!
GESCHWIND SYNDROME (personality changes with temporal epilepsy):
religiosity viscosity (increased experience of emotions) sexual behaviour change over-inclusive speech hypergraphia humorlessness hyperphagia
Akinetic mutism
“Vigilant coma”
From TUMOR in upper brainstem (ex: 3rd ventricle) or medial frontal lesion
Which AD in MDD in liver failure?
CELEXA
CIPRALEX
Child-Pugh scale
A (5-6) = 75-100% regular dose
B (7-9) = 50-75% regular dose
C (10-15) = 25-50% regular dose
Pseudoseizures
33% in patients with epilepsy
Less incontinence Less injuries Less nocturnal episodes Forced eye closure "Yes" or "no" head movements Pelvic thrusting No increased post-ictal prolactin No cyanosed skin post-ictal No confusion post-ictal Affected by suggestions
What is GESCHWIND SYNDROME
Personality changes with temporal lobe epilepsy:
hyperreligiosity
viscosity (increased experience of emotions)
sexual behaviour change
humorlessness
hyperphagia
Inter-ictal psychosis
More common in complex partial epilepsy
Especially in:
WOMEN
LEFT-HANDED
LEFT LESION
YOUNG ONSET
Treatment of MDD in epilepsy?
(6-50%)
CELEXA CIPRALEX SERTRALINE Lamictal Folate
Multiple Sclerosis
30-50% have COGNITIVE DISORDER especially memory
Does NOT correlate with severity or duration of illness
25-50% have depression, higher risk suicide
Careful with ADs as have higher prevalence of BAD
Pathological laughing/crying in 10%
Tx with SSRI or TCA
Chronic fatigue syndrome
At least 6 months of severe fatigue (causes decrease in at least 50% of activity)
+ at least 4 other symptoms
- memory/concentration difficulty
- sore throat
- tender lymph nodes
- muscle pain
- joint pain
- new headache
- unrefreshing sleep
- postexertional malaise lasting > 24 hours
Often SUDDEN onset
80% have DEPRESSION
LOW suicide rate
Often NO family history of depression
NOT associated with factitious disorder
Treatment with graded exercise therapy, some have response to amantadine (antiviral, also used in Parkinson’s)
Fibromyalgia
Consistent pain for at least 3 months
“Widespread pain index” at least 7
“ Symptom severity scale” at least 5
“Trigger points” most often in thoracic and cervical
Overlap +++ with MDD, PTSD, CFS (often comorbidity occurs BEFORE pain onset)
Other names:
- myalgic encephalitis
- functional encephalitis
- post-viral esthenia
- chronic mononucleosis
- royal free disease
Treatment with Pregabalin 150mg TID, analgesics, SNRI, acupuncture
Transplantation
20% depression or adjustment disorder in year post
10% have PTSD from procedure
Risk of relapse if sober < 6 months before liver transplant
Acute intermittent porphyria genes?
Autosomal dominant
Chromosome 11
Deficit in heme metabolism
F > M
Starts between 20-50 years old
Acute intermittent porphyria presentation
Triad of
- Abdominal pain
- Polyneuropathy (like GBS)
- Psychosis
Insomnia common early sign
Anxiety, agitation, phobia
Test: urinary porphobilinogen, urinary amino-levuliic acid
BARBITURATES can trigger or worsen attack
Can be caused by LEAD intoxication
Most anticholinergic TCA?
Amitriptyline
Least anticholinergic TCA?
Desipramine
Interferon (Hepatitis C)
Causes DEPRESSION in up to 50%
Biggest risk for MDE is at 12 weeks
Risk factor = PRE-EXISTING MDE
Risk does not correlate with dose or treatment duration
1st line = CELEXA, CIPRALEX
Pheochromocytoma
Causes ANXIETY
(Triad of headache, sweating, tachycardia)
Dose ACID VANYLMANDELIC (urinary catecholamines)
Serotonin syndrome
Diarrhea Tremor Myoclonus Hyperreflexia Hyperthermia Confusion/coma/stupor Euphoria/irritability Diaphoresis Sialorrhea
Abnormal labs rare
Complications: seizure/status epilepticus AKI metabolic ACIDOSIS hypotension / cardio collapse respiratory distress
Tx: cyproheptadine (SE antagonist), methysergide (SE antagonist)
NMS
0.01-0.02%
Mortality = 20-30%
Symptoms evolve quickly (24-72 hours)
Rigidity (lead pipe) Tremors Bradykinesia/akinesia Hyperthermia Altered mental status Mutism Dysphagia Urinary incontinence Hypertension or tachycardia Diaphoresis
Labs: Increased CK Leukocytosis Myoglobinuria Decreased Ca/Mg/Po4 Increased LDH Low iron
Complications: tachypnea/respiratory distress metabolic ACIDOSIS aspiration pneumonia pulmonary embolism
Risk factors: young male, AP naive injectable AP, fast increase agitation dehydration physical co-morbidity/neuro dysfunction
Protective factor:
Low potency APs with high anticholinergic effect (Clozapine, Zyprexa, Seroquel)
Tx: bromocriptine, dantrolene, amatadine, benzo, ECT
Kluver-Bucy
Acquired
BITEMPORAL (including amygdala)
Astereognosia + prosopagnosia Visual agnosia Flat affect Hypermetamorphosis Hyperorality Hypersexuality
Anton syndrome
Acquired
BLINDNESS AGNOSIA (failure to acknowledge blindness)
Bilateral occipital
Frequent causes are CVA, hypoxia, migraine
Balint syndrome
BILATERAL PARIETAL-OCCIPITAL
Optic ataxia
Oculomotor apraxia
Simultanagnosia
Gertsmann syndrome
DOMINANT PARIETAL
Digital agnosia Dysgraphia Acalculia Receptive aphasia (fluent aphasia) L/R disorientation
Non dominant parietal
Anosognosia
Denial
Contralateral hemineglect
Wernicke-Korsakoff
Bilateral mammillary bodies (median temporal)
Ataxia
Nystagmus
Amnesia (confabulation)
Psychosis
Causes:
EtOH
Hyperemesis gravidarum
Pyloric stenosis
Only 20% recuperate
Treat with thiamine (replete BEFORE glucose)
Wallenberg syndrome
LATERAL MEDULLARY SYNDROME
CVA of vertebral artery or inferior-posterior cerebellar
Ipsilateral facial pain/numbness Ipsilateral ataxia (fall to lesion side) Vertigo N/V Contralateral pain/thermal over body Dysphagia/hiccups
DOES NOT CAUSE AMAUROSIS FUGAX
Global transitory amnesia
Severe anterograde amnesia (repeats same question) Anxiety No insight Amnesic of episode No ictal period
Lasts 6-24 hours
MAYBE BILATERAL HIPPOCAMPUS LESION (temporo-median)
Higher in epilepsy, hypertension and migraine (compared to TIA)
Retain personal information and identity.
More common in MEN!
Carbon monoxide poisoning
GLOBUS PALLIDUS
Memory
Learning problems
Parkinsonism, dystonia (“flapping”)
Neuro sx can appear days later
Measles or measles vaccine
SUBACUTE SCLEROSING PANENCEPHALITIS
Herpes simplex encephalitis
Anosmia
Olfactory & gustatory hallucinations
Bizarre/psychotic personality
Rabies
HYDROPHOBIA (due to laryngeal and diaphragmatic spasms)
Restlessness
Overactivity
Agitation
Which AD to avoid in diabetes?
PROZAC (can cause hypoglycaemia)
TCA increases glucose but safe in controlled DM
Which AD for diabetic neuropathy?
CITALOPRAM
Depression more common in OPD or inpatient medical patients?
EQUAL
Attendance at OPD appointments better predicted by severity of depression than by underlying medical condition.
PROSPECT study?
People with diabetes and depression die less with depression care management (vs. usual care)
Adrenal insufficiency
Primary = Addison's Secondary = Sheehan's (post-partum necrosis of pituitary gland)
DEPRESSION
Hypercortisolism
Cushing’s syndrome
Causes:
pituitary tumor
pseudo (alcoholism)
exogenous steroids (psychiatric symptoms DOSE dependent)
24H urinary free cortisol > 100mcg
Moon face Buffalo hump Hirsutism Amenorrhea Erectile dysfunction Increased risk of fractures Glucose intolerance / weight gain Fatigue
QTc
Women < 460ms
Men < 450ms
Needs correction for HR Diurnal pattern (highest in morning)
QTc - (QRS - 100)
Gets prolonged from wide QRS
Risk factors for torsades de pointes
- Low Mg
- Low K
- Low Ca
- Women
- Age
Protective factor
- pacemaker
Citalopram prolongs QTc by how much?
10-20ms
Safest AP for QTc?
Abilify
Ziprasidone prolongs QTc by how much?
20ms
Quetiapine prolongs QTc by how much?
14.5ms
Risperidone prolongs QTc by how much?
10ms
EEG
Cerebral cortex layers 3 & 5 (pyramidal cells)
Childhood absence epilepsy
3Hz generalized spike-wave triggered by hyperventilation
Rx = ethosuximide
66% outgrow them