Pharmacology

Question 1

Zero order kinetics?

Answer 1

dose doesn’t matter - excretion of drug is constant:
20 -> 15 -> 10 -> 5 etc.

Eg - alcohol, phenytoin, theophylline, heparin

Question 2

First order kinetics?

Answer 2

dose dependent, excretion of drug is a percentage:
20 -> 10 -> 5 -> 2.5

Eg - most drugs

Question 3

Is protein binding higher or lower in neonates? What does this mean for concentration of drugs in the body?

Answer 3

Lower protein binding = higher free drug in the body

Question 4

Why phenobarbital over fosphenytoin?

Answer 4

fospheny has increased protein binding, more drug interactions