Pharmacology 5: Anthelmintics

Question 1

What are antiparasitic drugs?

Answer 1

Parasiticide= drug that kills parasites

Anthelmintic= drug that kills worms (helminths)

Pesticide= drug usually used for external parasites/arthropods (ECTOPARASITICIDE)
–> insecticide: kills insects
–>acaricide: kills ticks/mites

Question 2

All the anthelmintic drugs work against all the helminths?

Answer 2

False

Question 3

Any route of administration is equally effective for the antihelmintics drugs?

Answer 3

False

Question 4

What is extra label drug use (ELDU)?

Answer 4

Has to have label (TO USE)

use that is used in an other species or way that the label does not specifically state

Question 5

Who regulates the drugs we use?

Answer 5

FDA

Question 6

What do you need for FDA approval in bovine, ovine, caprine, equine, porcine, canina, feline, and poultry

Answer 6

90% of effectiveness (removal of adult worms)

Question 7

How is efficacy measured in anthelmintics?

Answer 7

WAAVP guidelines

Question 8

What are the 3 big groups of Anthelmintics?

Answer 8

Benzimidazoles and Pro-benzimidazoles

Nivotinic agonists

Macrocyclic lactones

Question 9

Benzinidazoles and pro-benzimidazoles
mode of action

do they need to get out of system fast?

Answer 9

Mode of action:
- slow parasite death; binds to beta-tubulin, prevents microtubule assembly, interferes with cell internal structure and metabolism

They need to STAY A WHILE TO work
-rumen and cecum act as a reservoir for absorption in ruminants and horses
-small animals usually need several doses

Question 10

Benzinidazoles and pro-benzimidazoles
spectrum of action?

Answer 10

Nematodes- primarily
-adulticidal, larvicidal, and ovicidal activity

Trematodes and Cestodes- adulticidal (ONLY IN RUMINANTS)