Parasite 6: Nematodes 5 Flashcards
Order Spirurida is described as?
Very long and thin
-confused with ascrid
What do all members of Spirurida have?
have an arthropod as intermediate host
Are Spirurida usually in the GIT?
NO not usually
What is the super family Filaroidea of Spirurida located?
What do Spirurida Filaroida a larvae (oviviparous) called?
Pre L1 = microfilariae
Dirofilaria immitis (Heart worm) is what kind of
host?
where is it located?
shape/length?
Definitive host = DOGS
Parasite of pulmonary arteries primarily (not IN HEART)
Long, thin; females up to 28cm in length
What is the life cycle of Dirofilaria immitis (Heart worm)?
Mosquito feeds and ingests microfilariae with blood
microfilaria matures in mosquito to infective L3 larva, 2 weeks post infection
infective larvae deposited during subsequent bites migrate through wound and into host
What is the PPP of Dirofilaria immitis (Heart worm)?
6 months
How long is the patency of Dirofilaria immitis (Heart worm)?
5 years
What is the pathogenesis of Dirofilaria immitis (Heart worm)?
Damage roughly proportional to worm numbers
* Probably no clinical signs with lower numbers
Disease components
* Some physical obstruction of vessel by worms
* Worms cause inflammation in vessel wall
* Progressive fibrosis in vessel (sclerosis)
Reduced cardiac output and compensatory right heart disease with severe disease
* Right heart enlargement and failure
Potential thromboembolism
Clinical signs of Dirofilaria immitis (heart worm)?
Chronic cough
Dyspnea
Decreased excercise tolerence
Where is the Prevalence of Dirofilaria immitis?
Highest:
along the MISSISSIPPI
and east coast
What is the best way to diagnosis Dirofilaria immitis?
Annual test recommended
Antigen tests: most sensitive and widely used
Microfilaria check
–> check peripheral blood sample for MF
Covered in detail in breathing and circulating
What is the treatment for Dirofilaria immitis?
PREVENTATIVES
Treatment is harsh and accompanied by risk of thromboembolism
What role of WOLBACHIA in Dirofilaria immitis?
Many, but not all filarid parasites have symbiotic bacteria,
Wolbachia
*If bacteria is removed, the reproduction of the worms is blocked, reduces severity of disease
*Doxycycline now being used in treatment of heartworm infections