Pharmacology

Question 1

give eg of 1st gen antipsychs and ADRs

Answer 1

haloperidol

iSHADE + weight gain

Question 2

ADRs of antipsychs

Answer 2

iSHADE

impotence, sedation, hypotension, anticholinergic, dermatological, endocrine (eg gyno)

Question 3

give egs of 2nd gen antipsychs

Answer 3

Rich Queens Are Clumsy Old Zillionaires

Risperidone, quetiapine, aripiprazole, clozapine, olanzapine, ziprasodine

Question 4

give the 5 types of drugs that can be used as anxiolytics and give egs and indication and MoA

Answer 4

BZDs - diazepam, lorazepam - ST anxiolytic - GABA(A)Rs
Antidepressants - LT anxiolytic
Buspirone - GAD (ST) - 5HT1A agonist
Beta blockers - Relieves somatic symptoms
Pregabalin - GAD - GABA(A)Rs

Question 5

ADRs of anxiolytics

Answer 5

Gi, headache, drowsiness, allergy, memory problems, confusion

Question 6

how treat ADHD

Answer 6

methylphenidate, atomoxetine

Question 7

ADRs of ADHD treatment

Answer 7

decreased appetite, GI, insomnia, headache

Question 8

give advice related to lithium

Answer 8

weekly blood tests, drink plenty of fluids, avoid caffeine

Question 9

egs of SSRIs

Answer 9

citalopram, fluoxetine, sertraline

Question 10

egs of TCAs

Answer 10

imipramine, amitryptiline

Question 11

egs of SNRI

Answer 11

venlafaxine, duloxetine

Question 12

what drug for nicotine dependence

Answer 12

bupropion

Question 13

drug for opioid dependence

Answer 13

naltrexone

Question 14

Hypnotic drugs? Indications?

Answer 14

Z-hyponotics eg zopiclone or zolpidem.

ST severe insomnia only

Question 15

Give NaSSA example and their indication

Answer 15

Mirtazapine

use in severe depression and PTSD

Question 16

Medication for dementia. When to use and examples

Answer 16

AChesterase inhibitors eg donezepil and galantamine. Mild to moderate dementia
NMDA receptor antagonists - memantine. Moderate to severe dementia

Question 17

Alcohol dependence drugs.. MoA and ADRs

Answer 17

Disulfiram. MoA - inhibits alcohol dehydrogenase. ADRs - fatigue and reduced libido
Acamprosate. MoA - prevents craving. ADRs - Gi, rash.

Question 18

Indications of sodium valproate

Answer 18

indication - bipolar, migraine prophylaxis

Question 19

adr and contraindications of sodium valproate

Answer 19

adr - tremor, sedation, thrombocytopenia

contra - hepatic impairment

Question 20

indications of carbamazepine

Answer 20

indication - bipolar, epilepsy

Question 21

adrs and contraindications of carbamazepine

Answer 21

adr - dizziness, hyponatremia, oedema, rash

contra - myelosuppression, acute porphyria

Question 22

monitoring and indications of lithium

Answer 22

monitor - serum conc after 1 week. 6 monthly LFT and U&E

indications - bipolar, unipolar depression

Question 23

adrs and contraindications of lithium

Answer 23

adr - LITHIUM - Leukocytosis, Int tremor, Teratogen, Hypothyroidism, Insipidus, Urine excess, Metallic taste
contraindications - addisons, hypothyroidism, cardiac rhythm disorder

Question 24

lithium toxicity signs

Answer 24

ataxia, convulsions, coma, dysarthria, tremor

Question 25

Benzo Toxicity Symptoms

Answer 25

Benzo BASH

Balance impaired, Ataxia, aggression, anterograde amnesia, Sleepy, Hallucinations, hypotension