Pharmacology

Question 1

What drug increases bile flow and is used in cholestatic liver diseases in dogs and cats?

Answer 1

ursodiol

Question 2

What drug has anti-inflammatory properties via inhibition of 5-lipoxygenase and is used in treating hepatic inflammation and necrosis?

Answer 2

silymarin (milk thistle)

Question 3

What is the MOA of lactulose?

Answer 3

converted to osmotically active acids in colon - traps ammonia

Question 4

What drug inhibits ammonia generation in colon and used in hepatic encephalopathy?

Answer 4

neomycin

Question 5

What drug is an antifibrotic and inhibits microtubules and procollagen?

Answer 5

colchicine - used in fibrotic liver dz

Question 6

What drug chelates plasma copper to allow urinary excretion and inhibits hepatic fibrosis?

Answer 6

D-penicillamine

Question 7

What is the MOA of methimazole?

Answer 7

inhibits thyroid peroxidase and thyroid hormone synthesis

Question 8

What is the MOA of trilostane?

Answer 8

inhibits adrenal enzyme 3-beta-hydroxysteroid dehydrogenase