Pharmacology

Question 1

Antibiotic w/ S/E of teeth discoloration

Answer 1

Tetracycline

Question 2

Antibiotic w/ S/E of tendonitis

Answer 2

Fluoroquinolone

Question 3

Antibiotic w/ S/E of red man syndrome

Answer 3

Vancomycin

Question 4

Antibiotic w/ S/E of gray baby syndrome

Answer 4

Chloramphenicol

Question 5

Antibiotic w/ S/E of cartilage damage in children

Answer 5

Fluoroquinolone

Question 6

Antibiotic w/ S/E of nephrotoxicity & ototoxicity

Answer 6

Aminoglycoside

Question 7

Antibiotic w/ S/E of pseudomembranous colitis

Answer 7

Clindamycin & Ampicilin (all Abx can)

Question 8

Safe antibiotics during pregnancy

Answer 8

penicillins, aminopenicillins, piperacillin, cephalosporin, macrolides, metronidazole (after 1st trimester), Nitrofurantoin

Question 9

Hydroxyurea MOA

Answer 9

inhibits Ribonucleotide reductase

Question 10

5’-Fluoruracil MOA

Answer 10

Irreversibly binds & inhibits Thymidylate Synthase

Question 11

Trimethoprim MOA

Answer 11

inhibits Dihydrofolate Reductase (prokaryotes)

Question 12

Methotrexate MOA

Answer 12

inhibits Dihydrofolate Reductase (eukaryotes)

Question 13

6-Mercaptopurine MOA

Answer 13

inhibits Glutamine PRPP Amidotransferase

Question 14

Mycophenolate MOA

Answer 14

inhibits IMP Dehydrogenase

Question 15

Ribavirin MOA

Answer 15

inhibits IMP Dehydrogenase

Question 16

Allopurinol MOA

Answer 16

Inhibits Xanthine Oxidase

Question 17

Febuxostat MOA

Answer 17

Inhibits Xanthine Oxidase

Question 18

Rifampin MOA

Answer 18

inhibits prokaryotic RNA pol

Question 19

Fluoroquinolone MOA

Answer 19

inhibits prokaryotic topoisomerase II (DNA gyrase)

Question 20

Trimethoprim MOA

Answer 20

inhibits prokaryotic dihydrofolate reductase

Question 21

Macrolides are used to tx infections w/ which agents?

Answer 21

P: atypical pneumonias (Legionella, Mycoplasma, Chlamydia pneumoniae)
U: URI (Group A Strep)
S: STD (N. gonorrhoeae, Chlamydia)

Question 22

Etoposide MOA

Answer 22

inhibits Topoisomerase

Question 23

Fluoroquinolone MOA

Answer 23

Topoisomerase

Question 24

Dantrolene MOA

Answer 24

prevents the release of Ca2+ from skeletal mm. SR

Question 25

Cocaine MOA

Answer 25

inhibits the reuptake of NE

Question 26

Tricyclic Antidepressants MOA

Answer 26

inhibits the reuptake of NE

Question 27

Aminoglycoside MOA

Answer 27

binds 30S subunit to prevent assembly w/ 50S

Question 28

Tetracycline MOA

Answer 28

binds 30S subunit to prevent aminoacyl tRNA binding w/ A site

Question 29

Chloramphenicol MOA

Answer 29

inhibits peptidyltransferase during translation

Question 30

Linezolid MOA

Answer 30

binds 50S subunit to prevent association w/ 30S

Question 31

Macrolide MOA

Answer 31

binds 50S subunit to prevent translocation during protein translation

Question 32

Clindamycin MOA

Answer 32

binds 50S subunit to prevent translocation during protein translation

Question 33

Lincomycin MOA

Answer 33

binds 50S subunit to prevent translocation during protein translation

Question 34

Streptogramin MOA

Answer 34

binds 50S subunit to prevent translocation during protein translation

Question 35

Atropine MOA

Answer 35

blocks muscarinic receptors

Question 36

Pralidoxime MOA

Answer 36

reactivates Acetylcholinesterase (used in organophosphate poisoning)

Question 37

Organophosphate poisoning effects?

Answer 37

inhibits Acetylcholinesterase —> excess ACh —-> increased PNS + excitation of nicotinic receptors at NMJ (mm. twitching) + excitation of muscarinic receptors on sweat glands (sympathetic control -> sweating)

Question 38

Hyperglycemia medication w/ S/E of lactic acidosis risk

Answer 38

Metformin